3-AMino-2-Chloro-isonicotinic acid ethyl ester

Base Information

• Chemical Name: 3-AMino-2-Chloro-isonicotinic acid ethyl ester
• CAS No.: 1093759-41-1
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.625
• Mol file: 1093759-41-1.mol

Synonyms:3-AMino-2-Chloro-isonicotinic acid ethyl ester;Ethyl 3-amino-2-chloroisonicotinate

Chemical Property of 3-AMino-2-Chloro-isonicotinic acid ethyl ester

Chemical Property:

• Boiling Point: 328.5±37.0 °C(Predicted)
• PKA: 1.17±0.10(Predicted)
• Density: 1.326±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-amino-2-chloroisonicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-AMino-2-Chloro-isonicotinic acid ethyl ester

There total 4 articles about 3-AMino-2-Chloro-isonicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

ethyl 3-aminopyridine-4-carboxylate (14208-83-4) → ethyl 3-amino-2-chloroisonicotinate (1093759-41-1) + ethyl 3-amino-2,6-dichloroisonicotinate

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; In water; at 0 - 20 ℃; for 1h;

Reference yield:

3,4-pyridinecarboxylic acid (490-11-9) → ethyl 3-amino-2-chloroisonicotinate (1093759-41-1) + ethyl 3-amino-2,6-dichloroisonicotinate

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic anhydride / 16 h / 140 °C

1.2: 8 h / 140 °C

2.1: sodium hydroxide; bromine / water / 8 h / 0 - 80 °C

3.1: sulfuric acid / 16 h / 0 - 95 °C

4.1: hydrogenchloride; dihydrogen peroxide / water / 1 h / 0 - 20 °C

With hydrogenchloride; sulfuric acid; dihydrogen peroxide; bromine; acetic anhydride; sodium hydroxide; In water;

Reference yield:

3,4-pyridinedicarboximide (4664-01-1) → ethyl 3-amino-2-chloroisonicotinate (1093759-41-1) + ethyl 3-amino-2,6-dichloroisonicotinate

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; bromine / water / 8 h / 0 - 80 °C

2: sulfuric acid / 16 h / 0 - 95 °C

3: hydrogenchloride; dihydrogen peroxide / water / 1 h / 0 - 20 °C

With hydrogenchloride; sulfuric acid; dihydrogen peroxide; bromine; sodium hydroxide; In water;

upstream raw materials:

3,4-pyridinecarboxylic acid

3,4-pyridinedicarboximide

3-Aminopyridine-4-carboxylic acid

ethyl 3-aminopyridine-4-carboxylate

Refernces