3,5-BIS(TRIFLUOROMETHYL)PHENYLTHIOETHANOL

Base Information

• Chemical Name: 3,5-BIS(TRIFLUOROMETHYL)PHENYLTHIOETHANOL
• CAS No.: 450409-97-9
• Molecular Formula: C10H8F6OS
• Molecular Weight: 290.23
• Hs Code.: 2930909090
• Mol file: 450409-97-9.mol

Synonyms:3,5-BIS(TRIFLUOROMETHYL)PHENYLTHIOETHANOL

Chemical Property of 3,5-BIS(TRIFLUOROMETHYL)PHENYLTHIOETHANOL

Chemical Property:

• PSA: 45.53000
• LogP: 3.80860

Purity/Quality:

99% ^*data from raw suppliers

3,5-BIS(TRIFLUOROMETHYL)PHENYLTHIOETHANOL 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-BIS(TRIFLUOROMETHYL)PHENYLTHIOETHANOL

There total 1 articles about 3,5-BIS(TRIFLUOROMETHYL)PHENYLTHIOETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,5-bis(trifluoromethyl)thiophenol (130783-02-7) + 2-bromoethanol (540-51-2) → 2-[3,5-di(trifluoromethyl)phenylsulfanyl]-1-ethanol (450409-97-9)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1055/s-2003-36844

Reference yield:

2-[3,5-di(trifluoromethyl)phenylsulfanyl]-1-ethanol (450409-97-9) → 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]-1-ethanol (450409-87-7)

Guidance literature:

With manganese(II) sulfate; dihydrogen peroxide; sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1016/S0040-4039(02)00598-1

Reference yield:

2-[3,5-di(trifluoromethyl)phenylsulfanyl]-1-ethanol (450409-97-9) → 3,5-bis(trifluoromethyl)phenyl vinyl sulfone (548740-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: MnSO₄; aq. H₂O₂; NaHCO₃ / acetonitrile / 20 °C

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 12 h / 20 °C

3: aq. NaHCO₃ / acetone / 12 h / 20 °C

With dmap; manganese(II) sulfate; dihydrogen peroxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone; acetonitrile;

DOI:10.1055/s-2003-36844

upstream raw materials:

3,5-bis(trifluoromethyl)thiophenol

2-bromoethanol

Downstream raw materials:

2-[3,5-bis(trifluoromethyl)phenylsulfonyl]-1-ethanol

3,5-bis(trifluoromethyl)phenyl vinyl sulfone

2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl butyrate

2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl 2-bromopropanoate

Refernces