3-BroMo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride

Base Information

• Chemical Name: 3-BroMo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride
• CAS No.: 905273-36-1
• Molecular Formula: C7H8BrClN2
• Molecular Weight: 235.50882
• Hs Code.: 2933990090
• Mol file: 905273-36-1.mol

Synonyms:3-BroMo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride;3-BroMo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine;3-BroMo-6,7-dihydro-5H-py...;3-BroMo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine.HCl;3-broMo-6,7-dihydro-5h-pyrrolo[3,4-b]pyridine 2hcl

Chemical Property of 3-BroMo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride

Chemical Property:

• Boiling Point: 253.9±40.0 °C(Predicted)
• PKA: 5.57±0.20(Predicted)
• PSA: 24.92000
• Density: 1.605±0.06 g/cm3(Predicted)
• LogP: 1.77610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine Hydrochloride is a starting material and useful building block of various pharmaceutical.

Technology Process of 3-BroMo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride

There total 7 articles about 3-BroMo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-bromo-6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (905273-35-0) → 3-bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (905273-36-1)

Guidance literature:

With trifluoroacetic acid; In methanol; chloroform; at 0 - 20 ℃;

Reference yield:

5-bromo-2,3-bis (bromomethyl) pyridine (905273-34-9) → 3-bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (905273-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 3 h / 60 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h

With hydrogenchloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c3md00280b

Reference yield:

3-bromo-5,6-dimethylpyridine (27063-90-7) → 3-bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (905273-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / Reflux

2: N,N-dimethyl-formamide / 3 h / 60 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In 1,4-dioxane; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c3md00280b

upstream raw materials:

3-bromo-6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

3-bromo-5,6-dimethylpyridine

5-bromo-2,3-bis (bromomethyl) pyridine

Pyridine-2,3-dicarboxylic acid

Downstream raw materials:

3-bromo-6-(tert-butoxycarbonyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

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