N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-N1-Methyl-1,2-ethanediaMine

Base Information

Chemical Name:N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-N1-Methyl-1,2-ethanediaMine
CAS No.:1391426-22-4
Molecular Formula:C23H23Cl2N5
Molecular Weight:440.36822
Hs Code.:
Mol file:1391426-22-4.mol

Synonyms:N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-N1-Methyl-1,2-ethanediaMine;LYS05

Suppliers and Price of N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-N1-Methyl-1,2-ethanediaMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine
250mg
$ 1390.00

Medical Isotopes, Inc.
N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine
250 mg
$ 2400.00

DC Chemicals
Lys05 >98%
1 g
$ 1700.00

DC Chemicals
Lys05 >98%
250 mg
$ 900.00

DC Chemicals
Lys05 >98%
100 mg
$ 500.00

Total 14 raw suppliers

Chemical Property of N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-N1-Methyl-1,2-ethanediaMine

Chemical Property:

Boiling Point:657.0±55.0 °C(Predicted)
PKA:8.23±0.50(Predicted)
PSA：53.08000
Density:1.356±0.06 g/cm3(Predicted)
LogP:5.69160
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly, Heated), Methanol (Slightly, Heated)

Purity/Quality:

99%, ^*data from raw suppliers

N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-N1-Methyl-1,2-ethanediaMine acts as an autophagy inhibitor, which removes the protection of cancer cells from various biological stresses.

Technology Process of N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-N1-Methyl-1,2-ethanediaMine

There total 3 articles about N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-N1-Methyl-1,2-ethanediaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 98519-65-4
7-chloro-4-bromo-quinoline

: 4097-88-5
1,5-diamino-3-azamethylpentane

: 1391426-22-4
N²-(7-Chloro-4-quinolinyl)-N¹-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N¹-methyl-1,2-ethanediamine

Guidance literature:: With potassium phosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 90 ℃; for 18h; Inert atmosphere;

Reference yield: 79.3%

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 4097-88-5
1,5-diamino-3-azamethylpentane

: 1391426-22-4
N²-(7-Chloro-4-quinolinyl)-N¹-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N¹-methyl-1,2-ethanediamine

Guidance literature:: In neat (no solvent); at 90 ℃; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00222

Reference yield:

: 86-99-7
7-chloro-4-hydroxylquinoline

: 1391426-22-4
N²-(7-Chloro-4-quinolinyl)-N¹-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N¹-methyl-1,2-ethanediamine

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; potassium phosphate / 1,4-dioxane; water / 16 h / 120 °C / Inert atmosphere; Sealed tube

With potassium phosphate; palladium diacetate; phosphorus tribromide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; N,N-dimethyl-formamide;