(5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanol

Base Information

• Chemical Name: (5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanol
• CAS No.: 1078575-71-9
• Molecular Formula: C12H18BNO3
• Molecular Weight: 235.091
• Hs Code.: 2933399990
• Mol file: 1078575-71-9.mol

Synonyms:(5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanol;6-(HydroxyMethyl)pyridine-3-boronic acid pinacol ester;2-(HydroxyMethyl)pyridine-5-boronic acid, pinacol ester

Chemical Property of (5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanol

Chemical Property:

• PSA: 51.58000
• LogP: 0.87310
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Hydroxymethyl)pyridine-5-boronic Acid Pinacol Ester is a reagent used in the identification of quinazoline based BRD4 inhibitors.

Technology Process of (5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanol

There total 2 articles about (5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-bromopyridin-2-yl)methanol (88139-91-7) + bis(pinacol)diborane (73183-34-3) → (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)methanol (1078575-71-9)

Guidance literature:

(5-bromopyridin-2-yl)methanol; bis(pinacol)diborane; With potassium acetate; In 1,4-dioxane; for 0.25h;

With tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 16.25h;

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + (5-bromopyridin-2-yl)methanol (88139-91-7) → (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)methanol (1078575-71-9)

Guidance literature:

With potassium acetate;

Reference yield: 52.0%

(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)methanol (1078575-71-9) + 3-(3-chloro-6-oxo-6H-pyridazin-1-ylmethyl)-benzoic acid methyl ester (1621689-03-9) → 3-[3-(6-hydroxymethylpyridin-3-yl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoic acid methyl ester (1621689-08-4)

Guidance literature:

(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)methanol; 3-(3-chloro-6-oxo-6H-pyridazin-1-ylmethyl)-benzoic acid methyl ester; In water; N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 3h;

upstream raw materials:

(5-bromopyridin-2-yl)methanol

bis(pinacol)diborane

1,4-dioxane

Downstream raw materials:

2-(6-(hydroxymethyl)pyridin-3-yl)-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one

3-[3-(6-hydroxymethylpyridin-3-yl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoic acid methyl ester

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