Technology Process of Ethyl 8-oxo-8-phenyloctanoate
There total 3 articles about Ethyl 8-oxo-8-phenyloctanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 7-iodoheptanoate;
With
chloro-trimethyl-silane; zinc; 1,1-dibromomethane;
In
tetrahydrofuran;
at 20 - 60 ℃;
for 16h;
With
lithium chloride;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
benzoyl chloride;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
Further stages.;
DOI:10.1021/jm020154k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 83 percent / NaI / acetone / Heating
2.1: Zn; (CH2)Br2; TMSCl / tetrahydrofuran / 16 h / 20 - 60 °C
2.2: CuCN; LiCl / tetrahydrofuran / 0.17 h / 0 °C
2.3: 80 percent / tetrahydrofuran / 3 h / 0 °C
With
chloro-trimethyl-silane; sodium iodide; zinc; 1,1-dibromomethane;
In
tetrahydrofuran; acetone;
DOI:10.1021/jm020154k
