methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate

Base Information

Chemical Name:methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate
CAS No.:1374516-35-4
Molecular Formula:C₂₄H₂₃FO₃
Molecular Weight:378.443
Hs Code.:

Synonyms:methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate

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Chemical Property of methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate

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Technology Process of methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate

There total 4 articles about methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: methyl 3-(4-((2-bromo-5-fluorobenzyl)oxy)phenyl)propanoate

: 5720-05-8
4-methylphenylboronic acid

: 1374516-35-4
methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; acetonitrile; at 75 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm300215x

Reference yield: 83.0%

: 1374516-35-4
methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; acetonitrile; at 75 ℃; Inert atmosphere;

Reference yield:

: 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester

: 1374516-35-4
methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 20 h / 75 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium iodide; In water; acetone; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/jm300215x