2-(4-bromophenyl)-2,2-difluoroacetic acid

Base Information

• Chemical Name: 2-(4-bromophenyl)-2,2-difluoroacetic acid
• CAS No.: 913574-93-3
• Molecular Formula: C8H5BrF2O2
• Molecular Weight: 251.027
• Hs Code.: 2916399090
• Mol file: 913574-93-3.mol

Synonyms:2-(4-bromophenyl)-2,2-difluoroacetic acid;4-Bromo-alpha,alpha-difluorobenzeneacetic acid

Chemical Property of 2-(4-bromophenyl)-2,2-difluoroacetic acid

Chemical Property:

• Boiling Point: 323℃
• Flash Point: 149℃
• PSA: 37.30000
• Density: 1.733
• LogP: 2.62550

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Bromophenyl)-2,2-difluoroacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(4-bromophenyl)-2,2-difluoroacetic acid

There total 7 articles about 2-(4-bromophenyl)-2,2-difluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 2-(4-bromophenyl)-2,2-difluoroacetic acid (913574-93-3)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 85.0%

2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester (1004305-97-8) → 2-(4-bromophenyl)-2,2-difluoroacetic acid (913574-93-3)

Guidance literature:

2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester; With water; potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 18h;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

Reference yield: 64.0%

1,4-bromoiodobenzene (589-87-7) + Ethyl bromodifluoroacetate (667-27-6) → 2-(4-bromophenyl)-2,2-difluoroacetic acid (913574-93-3)

Guidance literature:

1,4-bromoiodobenzene; Ethyl bromodifluoroacetate; With copper; In dimethyl sulfoxide; at 60 ℃; for 12h;

With potassium carbonate; In methanol; at 20 ℃; for 2h;

DOI:10.1021/acs.orglett.6b01188

upstream raw materials:

methyl 2-(4-bromophenyl)-2,2-difluoroacetate

2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester

1,4-bromoiodobenzene

Ethyl bromodifluoroacetate

Downstream raw materials:

p-bromo-α,α-difluorotoluene

p-trifluoromethylphenyl bromide

methyl 2-(4-bromophenyl)-2,2-difluoroacetate

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