1-Bromo-4-(bromodifluoromethyl)benzene

Base Information

• Chemical Name: 1-Bromo-4-(bromodifluoromethyl)benzene
• CAS No.: 2358-32-9
• Molecular Formula: C7H4Br2F2
• Molecular Weight: 285.914
• Mol file: 2358-32-9.mol

Synonyms:1-Bromo-4-(bromodifluoromethyl)benzene

Chemical Property of 1-Bromo-4-(bromodifluoromethyl)benzene

Chemical Property:

• PSA: 0.00000
• LogP: 3.89330

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-4-(bromodifluoromethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Bromo-4-(bromodifluoromethyl)benzene

There total 11 articles about 1-Bromo-4-(bromodifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-bromo-4-(difluoro((trifluoromethyl)sulfonyl)methyl)benzene → 1-bromo-4-(bromodifluoromethyl)benzene (2358-32-9)

Guidance literature:

With lithium bromide; In acetonitrile; at 80 ℃; for 12h; Schlenk technique; Glovebox;

DOI:10.1021/acs.orglett.1c03803

Reference yield: 82.0%

p-bromo-α,α-difluorotoluene (51776-71-7) → 1-bromo-4-(bromodifluoromethyl)benzene (2358-32-9)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 216h; Inert atmosphere; Irradiation;

DOI:10.1016/j.jfluchem.2016.12.017

Reference yield: 76.0%

2-(4-bromophenyl)-2,2-difluoroacetic acid (913574-93-3) → 1-bromo-4-(bromodifluoromethyl)benzene (2358-32-9)

Guidance literature:

With silver triflate-bis(1,10-phenanthroline) complex; dibromoisocyanuric acid; In dichloromethane; at 20 ℃; for 24h; Darkness; Inert atmosphere;

DOI:10.1021/jacs.1c05769

upstream raw materials:

1-bromo-4-(tribromomethyl)benzene

p-bromo-α,α-difluorotoluene

4-bromo-benzaldehyde

p-trifluoromethylphenyl bromide

Downstream raw materials:

{2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol

p-trifluoromethylphenyl bromide

5-((4-bromophenyl)difluoromethoxy)-1,2,3-trifluorobenzene