ethyl 2-(4-bromophenyl)-2,2-difluoroacetate

Base Information

• Chemical Name: ethyl 2-(4-bromophenyl)-2,2-difluoroacetate
• CAS No.: 1004305-97-8
• Molecular Formula: C₁₀H₉BrF₂O₂
• Molecular Weight: 279.081
• Hs Code.: 2916399090
• Mol file: 1004305-97-8.mol

Synonyms:ethyl 2-(4-bromophenyl)-2,2-difluoroacetate;Benzeneacetic acid, 4-bromo-α,α-difluoro-, ethyl ester;Ethyl 4-bromo-alpha,alpha-difluorobenzeneacetate;2-(4-Bromophenyl)-2,2-difluoroacetic acid ethyl ester

Chemical Property of ethyl 2-(4-bromophenyl)-2,2-difluoroacetate

Chemical Property:

• Boiling Point: 296.0±35.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.494±0.06 g/cm3(Predicted)
• LogP: 3.10400
• Storage Temp.: Room temperature.

Purity/Quality:

≥95% ^*data from raw suppliers

Ethyl2-(4-bromophenyl)-2,2-difluoroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(4-bromophenyl)-2,2-difluoroacetate

There total 10 articles about ethyl 2-(4-bromophenyl)-2,2-difluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Ethyl bromodifluoroacetate (667-27-6) + 4-Bromophenylboronic acid (5467-74-3) → 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester (1004305-97-8)

Guidance literature:

With [2,2]bipyridinyl; nickel(II) nitrate hexahydrate; potassium carbonate; In 1,4-dioxane; at 60 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201405653

Reference yield: 95.0%

→ 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester (1004305-97-8)

Guidance literature:

With copper; In dimethyl sulfoxide; at 30 - 50 ℃; for 16h; Inert atmosphere;

Reference yield: 81.1%

1,4-bromoiodobenzene (589-87-7) + Ethyl bromodifluoroacetate (667-27-6) → 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester (1004305-97-8)

Guidance literature:

Ethyl bromodifluoroacetate; With copper; In dimethyl sulfoxide; at 20 ℃; for 1.5h;

1,4-bromoiodobenzene; In dimethyl sulfoxide; at 20 ℃; for 24h;

upstream raw materials:

ethyl 4-bromophenylglyoxylate

1,4-bromoiodobenzene

α-(trimethylsilyl)difluoroacetic acid ethyl ester

Ethyl bromodifluoroacetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1004305-97-8 ethyl 2-(4-bromophenyl)-2,2-difluoroacetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send