3-(2-Methoxyethylaminocarbonyl)benzeneboronic acid pinacol ester

Base Information

• Chemical Name: 3-(2-Methoxyethylaminocarbonyl)benzeneboronic acid pinacol ester
• CAS No.: 1073353-64-6
• Molecular Formula: C₁₆H₂₄BNO₄
• Molecular Weight: 305.182
• Hs Code.: 2931900090
• Mol file: 1073353-64-6.mol

Synonyms:3-(2-Methoxyethylaminocarbonyl)benzeneboronic acid pinacol ester;3-(2-METHOXYETHYLCARBAMOYL)PHENYLBORONIC ACID, PINACOL ESTER;N-(2-METHOXYETHYL)-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZAMIDE;[3-(2-Methoxyethylamine-1-carbonyl)-phenyl]boronic acid pinacol ester

Chemical Property of 3-(2-Methoxyethylaminocarbonyl)benzeneboronic acid pinacol ester

Chemical Property:

• Melting Point: 93-98°C
• PSA: 56.79000
• LogP: 1.75290
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

3-(2-Methoxyethylcarbamoyl)phenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Methoxyethylaminocarbonyl)benzeneboronic acid pinacol ester

There total 2 articles about 3-(2-Methoxyethylaminocarbonyl)benzeneboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-N-(2-methoxyethyl)benzamide (349405-25-0) + bis(pinacol)diborane (73183-34-3) → C16H24BNO4 (1073353-64-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113482

Reference yield:

m-bromobenzoic acid (585-76-2) → C16H24BNO4 (1073353-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 5 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.ejmech.2021.113482

Reference yield: 27.0%

3-iodo-5-(4-isopropyl-4H-1,2,4-triazol-3-yl)-1H-indazole + C16H24BNO4 (1073353-64-6) → 3-(5-(4-isopropyl-4H-1,2,4-triazol-3-yl)-1H-indazol-3-yl)-N-(2-methoxyethyl)benzeneformamide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.ejmech.2021.113482

upstream raw materials:

3-bromo-N-(2-methoxyethyl)benzamide

bis(pinacol)diborane

m-bromobenzoic acid

Refernces