2-Bromo-4-vinylpyridine

Base Information

• Chemical Name: 2-Bromo-4-vinylpyridine
• CAS No.: 697300-78-0
• Molecular Formula: C₇H₆BrN
• Molecular Weight: 184.035
• DSSTox Substance ID: DTXSID20591460
• Wikidata: Q82485229
• Mol file: 697300-78-0.mol

Synonyms:2-Bromo-4-vinylpyridine;697300-78-0;2-bromo-4-ethenylpyridine;SCHEMBL5974138;DTXSID20591460;MFCD23135676;AKOS016002775;SB54521;AS-37606;CS-0227050;A866765;J-400260

Chemical Property of 2-Bromo-4-vinylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.48710
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 182.96836
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4-vinylpyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CC1=CC(=NC=C1)Br

Technology Process of 2-Bromo-4-vinylpyridine

There total 2 articles about 2-Bromo-4-vinylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 2-bromopyridine-4-carboxaldehyde (118289-17-1) → 2-bromo-4-vinylpyridine (697300-78-0)

Guidance literature:

Methyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

2-bromopyridine-4-carboxaldehyde; In tetrahydrofuran; at -78 - 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/jacs.1c07402

Reference yield: 75.2%

2-bromo-4-iodo-pyridine (100523-96-4) + tri-n-butyl(vinyl)tin (7486-35-3) → 2-bromo-4-vinylpyridine (697300-78-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 - 125 ℃;

DOI:10.1021/jm030432v

upstream raw materials:

2-bromo-4-iodo-pyridine

tri-n-butyl(vinyl)tin

Methyltriphenylphosphonium bromide

2-bromopyridine-4-carboxaldehyde