3-(Piperidin-4-yl)pyridine

Base Information

• Chemical Name: 3-(Piperidin-4-yl)pyridine
• CAS No.: 161609-89-8
• Molecular Formula: C10H14N2
• Molecular Weight: 162.235
• European Community (EC) Number: 852-608-8
• DSSTox Substance ID: DTXSID50405602
• Nikkaji Number: J849.761C
• Wikidata: Q82210228
• Mol file: 161609-89-8.mol

Synonyms:3-(Piperidin-4-yl)pyridine;161609-89-8;3-piperidin-4-ylpyridine;Pyridine, 3-(4-piperidinyl)-;4-pyrid-3-ylpiperidine;4-(3-pyridyl)piperidine;SCHEMBL533875;DTXSID50405602;BRBPGGIIQVBPSB-UHFFFAOYSA-N;MFCD05189896;AKOS000209139;SB42857;CS-0308449;FT-0713186;C14989;EN300-120403;F2148-0198

Chemical Property of 3-(Piperidin-4-yl)pyridine

Chemical Property:

• Boiling Point: 281.6±33.0 °C(Predicted)
• PKA: 9.99±0.10(Predicted)
• PSA: 24.92000
• Density: 1.014±0.06 g/cm3(Predicted)
• LogP: 1.87740
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.115698455
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

99% ^*data from raw suppliers

3-(Piperidin-4-yl)pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1C2=CN=CC=C2

Technology Process of 3-(Piperidin-4-yl)pyridine

There total 7 articles about 3-(Piperidin-4-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(1-benzylpiperidin-4-yl)pyridine (1018826-73-7) → 3-(piperidin-4-yl)pyridine (161609-89-8)

Guidance literature:

With hydrogen; palladium dihydroxide; acetic acid; In methanol; at 23 ℃; for 16h;

Reference yield:

tert-butyl 4-(pyridin-3-yl)piperidine-1-carboxylate (550371-77-2) → 3-(piperidin-4-yl)pyridine (161609-89-8)

Guidance literature:

DOI:10.1016/j.bmcl.2007.12.029

Reference yield:

3,4'-bipyridyl (4394-11-0) → 3-(piperidin-4-yl)pyridine (161609-89-8)

Guidance literature:

With hydrogenchloride; tin;

DOI:10.1021/ja01352a038

upstream raw materials:

3,4'-bipyridyl

tert-butyl 4-(pyridin-3-yl)piperidine-1-carboxylate

3-(1-benzylpiperidin-4-yl)pyridine

3-Bromopyridine

Refernces

• 1、 Palacios, Daniel S.,Meredith, Erik L.,Kawanami, Toshio,Adams, Christopher M.,Chen, Xin,Darsigny, Veronique,Palermo, Mark,Baird, Daniel,George, Elizabeth L.,Guy, Chantale,Hewett, Jeffrey,Tierney, Laryssa,Thigale, Sachin,Wang, Louis,Weihofen, Wilhelm A.. "Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT)". supporting information. p. 1524 - 1529. Retrieved 2019/11/03.
• 2、 -. "PYRROLOTRIAZINE KINASE INHIBITORS". Page/Page column 60. . Retrieved 2008/06/13.