4-(3-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-(3-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:550371-77-2
Molecular Formula:C15H22N2O2
Molecular Weight:262.35
Hs Code.:2933990090
Mol file:550371-77-2.mol

Synonyms:4-(3-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Suppliers and Price of 4-(3-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 4-(3-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Boiling Point:375.3±35.0 °C(Predicted)
PKA:5.34±0.12(Predicted)
PSA：42.43000
Density:1.083±0.06 g/cm3(Predicted)
LogP:3.13400

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-(3-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 15 articles about 4-(3-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: pyridine-3-ylmagnesium bromide lithium chloride adduct

: 301673-14-3
tert-butyl 4-iodopiperidine-1-carboxylate

: 550371-77-2
tert-butyl 4-(pyridin-3-yl)piperidine-1-carboxylate

Guidance literature:: With (1R,2R)-bis(dimethylamino)cyclohexane; cobalt(II) chloride; In tetrahydrofuran; at -10 ℃; Inert atmosphere;
DOI:10.1002/chem.201501543

Reference yield: 62.0%

: 626-55-1,163928-56-1
3-Bromopyridine

: 301673-14-3
tert-butyl 4-iodopiperidine-1-carboxylate

: 550371-77-2
tert-butyl 4-(pyridin-3-yl)piperidine-1-carboxylate

Guidance literature:: 3-Bromopyridine; With diisobutylaluminium hydride; magnesium; lithium chloride; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

tert-butyl 4-iodopiperidine-1-carboxylate; With cobalt(II) chloride; In tetrahydrofuran; at -10 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol503043r

Reference yield: 43.0%

: 626-55-1,163928-56-1
3-Bromopyridine

: 180695-79-8
tert-butyl 4-bromo-1-piperidinecarboxylate

: 550371-77-2
tert-butyl 4-(pyridin-3-yl)piperidine-1-carboxylate

Guidance literature:: With 4-Ethylpyridine; manganese; sodium tetrafluoroborate; 1,10-Phenanthroline; (1,2-dimethoxyethane)dichloronickel(II); In methanol; at 60 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jo500905m