11-Ketodehydroepiandrosterone

Base Information

Chemical Name:11-Ketodehydroepiandrosterone
CAS No.:17520-02-4
Molecular Formula:C₁₉H₂₆O₃
Molecular Weight:302.414
Hs Code.:
DSSTox Substance ID:DTXSID701043175
Mol file:17520-02-4.mol

Synonyms:11-KETODEHYDROEPIANDROSTERONE;17520-02-4;(3S,8S,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-11,17-dione;SCHEMBL22446786;DTXSID701043175;5-Androsten-3beta-ol-11,17-dione

Suppliers and Price of 11-Ketodehydroepiandrosterone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 11-Ketodehydroepiandrosterone

Chemical Property:

PSA：54.37000
LogP:3.05820
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:302.18819469
Heavy Atom Count:22
Complexity:577

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC(CC1=CCC3C2C(=O)CC4(C3CCC4=O)C)O
Isomeric SMILES:C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CCC4=O)C)O

Technology Process of 11-Ketodehydroepiandrosterone

There total 10 articles about 11-Ketodehydroepiandrosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 118319-81-6
3β-(t-butyldimethylsilyloxy)androst-5-en-11,17-dione

: 17520-02-4
3β-Hydroxy-androsten-(5)-dion-(11,17)

Guidance literature:: With toluene-4-sulfonic acid; In methanol; water; acetone; for 10h; Ambient temperature;
DOI:10.1016/S0040-4020(01)82010-X

Reference yield:

: C₂₁H₃₂O₅

: 17520-02-4
3β-Hydroxy-androsten-(5)-dion-(11,17)

Guidance literature:: With periodic acid; In methanol; at 0 - 20 ℃; for 6h;

Reference yield:

: 382-45-6
adrenosterone

: 17520-02-4
3β-Hydroxy-androsten-(5)-dion-(11,17)

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) acetylation, 2.) Ca(BH₄)2 / 2.) ethanol, -15 deg C

2: 85 percent / 1,8-diazobicyclo<5.4.0>undec-7-ene (DBU) / tetrahydrofuran

3: 98 percent / pyridinium dichromate (PDC) / CH₂Cl₂

4: p-toluenesulfonic acid / H₂O; acetone; methanol

With dipyridinium dichromate; calcium borohydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/jo00262a013