1-(4-Bromopyridin-2-yl)-4-methylpiperazine

Base Information

• Chemical Name: 1-(4-Bromopyridin-2-yl)-4-methylpiperazine
• CAS No.: 1060812-92-1
• Molecular Formula: C10H14BrN3
• Molecular Weight: 256.145
• Hs Code.: 2933990090
• Mol file: 1060812-92-1.mol

Synonyms:1-(4-Bromopyridin-2-yl)-4-methylpiperazine;4-Bromo-2-(4-methylpiperazino)pyridine;4-Bromo-2-(N-methylpiperazin-1-yl)pyridine

Chemical Property of 1-(4-Bromopyridin-2-yl)-4-methylpiperazine

Chemical Property:

• PSA: 19.37000
• LogP: 1.59880
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-(4-methylpiperazino)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Bromopyridin-2-yl)-4-methylpiperazine

There total 2 articles about 1-(4-Bromopyridin-2-yl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.9%

1-methyl-piperazine (109-01-3) + 2-chloro-4-bromopyridine (73583-37-6) → 1-(4-bromopyridin-2-yl)-4-methylpiperazine (1060812-92-1)

Guidance literature:

With triethylamine; In ethanol; at 80 ℃; for 100h;

Reference yield:

1-methyl-piperazine (109-01-3) + 4-bromo-2-fluoropyridine (128071-98-7) → 1-(4-bromopyridin-2-yl)-4-methylpiperazine (1060812-92-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 2h;

Reference yield: 49.0%

N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin (1426260-18-5) + 1-(4-bromopyridin-2-yl)-4-methylpiperazine (1060812-92-1) → 4-{4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]phenyl}-N-(6-methylpyridin-2-yl)thiazol-2-amine (1426259-59-7)

Guidance literature:

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

DOI:10.1002/cmdc.201300007

upstream raw materials:

1-methyl-piperazine

2-chloro-4-bromopyridine

4-bromo-2-fluoropyridine

Downstream raw materials:

N-(4-{4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]phenyl}thiazol-2-yl)cyclopropanecarboxamide

4-{4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]phenyl}-N-(6-methylpyridin-2-yl)thiazol-2-amine

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