N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin

Base Information

Chemical Name:N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin
CAS No.:1426260-18-5
Molecular Formula:C₂₁H₂₄BN₃O₂S
Molecular Weight:393.317
Hs Code.:

Synonyms:N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin

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Chemical Property of N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin

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Technology Process of N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin

There total 6 articles about N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1310049-89-8
[4-(4-bromophenyl)-1,3-thiazol-2-yl]-(6-methylpyridin-2-yl)amine

: 73183-34-3
bis(pinacol)diborane

: 1426260-18-5
N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201300007

Reference yield:

: 1824-81-3
2-Amino-6-methylpyridine

: 1426260-18-5
N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin

Guidance literature:: Multi-step reaction with 4 steps

1: acetone / Reflux

2: sodium hydroxide / methanol / 0.5 h / Reflux

3: ethanol / 3 h / Reflux

4: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; acetone; 3: |Hantzsch Thiazole Synthesis / 4: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201300007

Reference yield:

: 96938-51-1
N-(6-methylpyridine-2-ylcarbamothioyl)benzamide

: 1426260-18-5
N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 0.5 h / Reflux

2: ethanol / 3 h / Reflux

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; 2: |Hantzsch Thiazole Synthesis / 3: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201300007