TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER

Base Information

Chemical Name:TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER
CAS No.:1188366-14-4
Molecular Formula:C₁₃H₂₃NO₅
Molecular Weight:273.329
Hs Code.:
Mol file:1188366-14-4.mol

Synonyms:TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER;METHYL N-BOC-A-(TETRAHYDRO-4-H-PYRANYL) GLYCINATE;2H-Pyran-4-acetic acid, a-[[(1,1-diMethylethoxy)carbonyl]aMino]tetrahydro-, Methyl ester

Suppliers and Price of TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER 95.00%
5MG
$ 497.57

Total 3 raw suppliers

Chemical Property of TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER

Chemical Property:

Boiling Point:383.3±17.0 °C(Predicted)
PKA:10.96±0.46(Predicted)
PSA：77.35000
Density:1.102±0.06 g/cm3(Predicted)
LogP:1.68370

Purity/Quality:

97% ^*data from raw suppliers

TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER

There total 3 articles about TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 477585-43-6,871301-35-8
methyl 2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate

: 24424-99-5
di-tert-butyl dicarbonate

: 1188366-14-4
methyl 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetate

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 25 ℃; for 2h;

Reference yield:

: 477584-90-0
methyl 2-(((benzyloxy)carbonyl)amino)-2-(dihydro-2H-pyran-4(3H)-ylidene)acetate

: 1188366-14-4
methyl 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 25 °C / Inert atmosphere

2: sodium carbonate / water; 1,4-dioxane / 2 h / 25 °C

With palladium on activated charcoal; hydrogen; sodium carbonate; In 1,4-dioxane; methanol; water;

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 1188366-14-4
methyl 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 10 - 35 °C

1.2: 10 - 35 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 10 - 35 °C / 760.05 Torr

3.1: triethylamine / tetrahydrofuran / 5 h / 10 - 35 °C

With palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; acetonitrile;