TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID

Base Information

• Chemical Name: TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID
• CAS No.: 182287-49-6
• Molecular Formula: C12H21 N O5
• Molecular Weight: 259.302
• Hs Code.: 2932999099
• Mol file: 182287-49-6.mol

Synonyms:TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID;N-BOC-2-(TETRAHYDRO-PYRAN-4-YL)-GLYCINE;N-BOC-4’-TETRAHYDROPYRANYLGLYCINE

Chemical Property of TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID

Chemical Property:

• Vapor Pressure: 2.34E-08mmHg at 25°C
• Refractive Index: 1.486
• Boiling Point: 423.5°Cat760mmHg
• PKA: 3.81±0.10(Predicted)
• Flash Point: 209.9°C
• PSA: 84.86000
• Density: 1.164g/cm³
• LogP: 1.78180
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-{[(tert-Butoxy)carbonyl]amino}-2-(oxan-4-yl)acetic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID

There total 4 articles about TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

methyl 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetate (1188366-14-4) → 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid (182287-49-6)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 10 - 35 ℃;

Reference yield:

methyl 2-(((benzyloxy)carbonyl)amino)-2-(dihydro-2H-pyran-4(3H)-ylidene)acetate (477584-90-0) → 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid (182287-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 25 °C / Inert atmosphere

2.1: sodium carbonate / water; 1,4-dioxane / 2 h / 25 °C

3.1: sodium hydroxide / methanol / 2 h / 25 °C

3.2: pH 3

With palladium on activated charcoal; hydrogen; sodium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; water;

Reference yield:

methyl 2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate (477585-43-6,871301-35-8) → 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid (182287-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / water; 1,4-dioxane / 2 h / 25 °C

2.1: sodium hydroxide / methanol / 2 h / 25 °C

2.2: pH 3

With sodium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; water;

upstream raw materials:

methyl 2-(((benzyloxy)carbonyl)amino)-2-(dihydro-2H-pyran-4(3H)-ylidene)acetate

methyl 2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate

methyl 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetate

Tetrahydro-4H-pyran-4-one

Refernces

• 1、 -. "SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS". . . Retrieved 2013/09/26.