4,4,5,5-TETRAMETHYL-2-(SPIRO[4.5]DEC-7-EN-8-YL)-1,3,2-DIOXABOROLANE

Base Information

Chemical Name:4,4,5,5-TETRAMETHYL-2-(SPIRO[4.5]DEC-7-EN-8-YL)-1,3,2-DIOXABOROLANE
CAS No.:859219-41-3
Molecular Formula:C₁₆H₂₇BO₂
Molecular Weight:262.2
Hs Code.:
Mol file:859219-41-3.mol

Synonyms:4,4,5,5-TETRAMETHYL-2-(SPIRO[4.5]DEC-7-EN-8-YL)-1,3,2-DIOXABOROLANE

Suppliers and Price of 4,4,5,5-TETRAMETHYL-2-(SPIRO[4.5]DEC-7-EN-8-YL)-1,3,2-DIOXABOROLANE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,4,5,5-Tetramethyl-2-{spiro[4.5]dec-7-en-8-yl}-1,3,2-dioxaborolane
100mg
$ 165.00

Medical Isotopes, Inc.
4,4,5,5-Tetramethyl-2-[spiro[4.5]dec-7-en-8-yl]-1,3,2-dioxaborolane
1 g
$ 2200.00

Crysdot
4,4,5,5-Tetramethyl-2-(spiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 95+%
100mg
$ 644.00

Total 6 raw suppliers

Chemical Property of 4,4,5,5-TETRAMETHYL-2-(SPIRO[4.5]DEC-7-EN-8-YL)-1,3,2-DIOXABOROLANE

Chemical Property:

PSA：18.46000
LogP:4.28850

Purity/Quality:

97% ^*data from raw suppliers

4,4,5,5-Tetramethyl-2-{spiro[4.5]dec-7-en-8-yl}-1,3,2-dioxaborolane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4,4,5,5-Tetramethyl-2-{spiro[4.5]dec-7-en-8-yl}-1,3,2-dioxaborolane is used as a reagent in the preparation of imidazolecarboxamide compounds as c-Fms kinase inhibitors. These inhibitors are useful in the prevention of diseases which include autoimmune diseases.

Technology Process of 4,4,5,5-TETRAMETHYL-2-(SPIRO[4.5]DEC-7-EN-8-YL)-1,3,2-DIOXABOROLANE

There total 4 articles about 4,4,5,5-TETRAMETHYL-2-(SPIRO[4.5]DEC-7-EN-8-YL)-1,3,2-DIOXABOROLANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: spiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate

: 73183-34-3
bis(pinacol)diborane

: 859219-41-3
4,4,5,5-tetramethyl-2-(spiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 14523-53-6
spiro<4.5>dec-6-en-8-one

: 859219-41-3
4,4,5,5-tetramethyl-2-(spiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 16 h

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

With n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium acetate; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 872-53-7
cyclopentanealdehyde

: 859219-41-3
4,4,5,5-tetramethyl-2-(spiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / toluene / 3.5 h / 45 °C / Reflux; Dean-Stark

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 16 h

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

With n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium acetate; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene;