Technology Process of 2-Chloro-3-(2-fluorophenyl)-3-oxopropanenitrile
There total 2 articles about 2-Chloro-3-(2-fluorophenyl)-3-oxopropanenitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
acetonitrile;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
methyl 2-chloro-6-fluorobenzoate;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sulfuric acid / 3 h / 110 °C / Microwave irradiation
2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 - 20 °C
With
n-butyllithium; sulfuric acid; diisopropylamine;
In
tetrahydrofuran; hexane;
- Guidance literature:
-
With
hydrazine hydrate;
In
ethanol;
at 120 ℃;
for 3h;
Microwave irradiation;