7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline

Base Information

Chemical Name:7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline
CAS No.:774549-97-2
Molecular Formula:C19H17Cl2N3O2S
Molecular Weight:422.335
Hs Code.:2935009090
European Community (EC) Number:633-302-1
DSSTox Substance ID:DTXSID40361304
Wikidata:Q82143580
ChEMBL ID:CHEMBL1905600
Mol file:774549-97-2.mol

Synonyms:KM11060;774549-97-2;KM 11060;7-chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline;7-chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)quinoline;KM-11060;7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline;7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline;D06TCC;Oprea1_790000;GTPL4234;CHEMBL1905600;SCHEMBL15774887;DTXSID40361304;AMY39825;BCP17185;EX-A5067;ZFB54997;7-chloro-4-{4-[(4-chlorobenzene)sulfonyl]piperazin-1-yl}quinoline;CCG-44815;s6599;STK206351;AKOS000424630;CS-5499;NCGC00378786-01;AC-35421;AS-55981;HY-19970;EC-000.2090;EN300-39137;KM11060, >=98% (HPLC);C76482;A901612;SR-01000634629-1;BRD-K32856097-001-01-4;Z31097998;7-chloro-4-(4-((4-chlorophenyl)sulfonyl)-1-piperazinyl)quinoline;7-Chloro-4-[4-(4-chloro-benzenesulfonyl)-piperazin-1-yl]-quinoline;7-chloro-4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]quinoline;7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-Quinoline

Suppliers and Price of 7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
KM 11060
10mg
$ 409.00

TRC
KM11060
1mg
$ 45.00

Tocris
KM11060 ≥98%(HPLC)
50
$ 483.00

Tocris
KM11060 ≥98%(HPLC)
10
$ 116.00

DC Chemicals
KM11060 >98%
100 mg
$ 300.00

DC Chemicals
KM11060 >98%
1 g
$ 1200.00

Crysdot
KM11060 98+%
100mg
$ 697.00

Crysdot
KM11060 98+%
50mg
$ 395.00

ChemScene
KM11060 99.80%
100mg
$ 490.00

ChemScene
KM11060 99.80%
10mg
$ 70.00

Total 17 raw suppliers

Chemical Property of 7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline

Chemical Property:

Vapor Pressure:1.07E-14mmHg at 25°C
Boiling Point:607.3°C at 760 mmHg
Flash Point:321.1°C
PSA：61.89000
Density:1.449g/cm³
LogP:5.13620
Storage Temp.:Store at RT
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:421.0418534
Heavy Atom Count:27
Complexity:599

Purity/Quality:

99%, ^*data from raw suppliers

KM 11060 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=CC=C(C=C4)Cl
Uses KM 11060 is a small molecular corrector of F508del CFTR trafficking, which has potential application in cystic fibrosis therapeutics.

Technology Process of 7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline

There total 2 articles about 7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.3%

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 837-52-5
7-chloro-4-piperazinylquinoline

: 774549-97-2
7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2013.03.052

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 774549-97-2
7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 12 h / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C

With triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2013.03.052