(R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium

Base Information

Chemical Name:(R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium
CAS No.:754919-24-9
Molecular Formula:C₂₀H₂₄NO₂
Molecular Weight:310.416
Hs Code.:
Mol file:754919-24-9.mol

Synonyms:(R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium;N-Methylnuciferine

Suppliers and Price of (R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Methylnuciferine
20mg
$ 638.00

ChemScene
N-Methylnuciferine
10mg
$ 514.00

ChemScene
N-Methylnuciferine
5mg
$ 303.00

Arctom
N-Methylnuciferine ≥98%
5mg
$ 653.00

Total 24 raw suppliers

Chemical Property of (R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium

Chemical Property:

PSA：18.46000
LogP:3.55930

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

N-Methylnuciferine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium

There total 7 articles about (R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 5868-18-8
nuciferine

: 74-88-4
methyl iodide

: 754919-24-9
C₂₀H₂₄NO₂⁽¹⁺⁾

Guidance literature:: In methanol; diethyl ether; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2013.06.078

Reference yield: 78.0%

: 1,2-dimethoxy-4,5,6a,7-tetrahydrodibenzo[de,g]quinoline-6-carboxylic acid tert-butyl ester

: 754919-24-9
C₂₀H₂₄NO₂⁽¹⁺⁾

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Reflux;
DOI:10.1016/j.bmcl.2013.06.078

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 754919-24-9
C₂₀H₂₄NO₂⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / dichloromethane; water / 16 h / 20 °C

2: trichlorophosphate / acetonitrile / 1 h / Inert atmosphere; Reflux

3: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere

4: dichloromethane / 2 h / 20 °C

5: palladium diacetate; potassium carbonate; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine / N,N-dimethyl acetamide / 4 h / 130 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

With sodium tetrahydroborate; lithium aluminium tetrahydride; palladium diacetate; potassium carbonate; sodium hydroxide; trichlorophosphate; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;
DOI:10.1016/j.bmcl.2013.06.078