(9aR)-Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride

Base Information

• Chemical Name: (9aR)-Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride
• CAS No.: 1126432-04-9
• Molecular Formula: C7H16Cl2N2O
• Molecular Weight: 215.12074
• Hs Code.: 2934999090
• Mol file: 1126432-04-9.mol

Synonyms:(9aR)-Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride;(9aR)-octahydropiperazino[2,1-c]morpholine dihydrochloride;(R)-OCTAHYDROPYRAZINO[2,1-C][1,4]OXAZINE;(9AR)-Octahydropyrazino[2,1-c][1,4]oxazine (hydrochloride)(1:2)

Chemical Property of (9aR)-Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride

Chemical Property:

• PSA: 24.50000
• LogP: 1.16110
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

(9aR)-Octahydropiperazino[2,1-c]morpholineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (9aR)-Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride

There total 13 articles about (9aR)-Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(9aR)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine (1126432-05-0) → (9aR)-octahydropyrazino[2,1-c][1,4]oxazine hydrochloride (1244641-57-3,1126432-04-9,1257998-65-4,1089280-14-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium-on-charcoal; In methanol; water; at 20 ℃;

Reference yield: 62.0%

(9aR)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine (1126432-05-0) → (9aR)-octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride (1126432-04-9,1257998-65-4,1089280-14-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water;

Reference yield: 52.0%

(9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine (1089280-13-6) → (9aS)-1,3,4,6,7,8,9,9a-octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride (1126432-04-9,1257998-65-4,1089280-14-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; under 760.051 Torr;

upstream raw materials:

(9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

(3R)-5-oxo-4-(phenylmethyl)-3-morpholinecarboxylic acid

(3R)-5-oxo-N,4-bis(phenylmethyl)-3-morpholinecarboxamide

1-phenyl-N-{[(3S)-4-(phenylmethyl)-3-morpholinyl]methyl}methanamine

Downstream raw materials:

[(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-4-pyrimidinyl}hydrazino)-3-oxopropyl][(phenylmethyl)oxy]formamide

GSK1322322

(S)-octahydropyrazino[2,1-c][1,4]oxazine

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