Cyclopentanepropanoic acid, α-[(forMylhydroxyaMino)Methyl]-, 2-[5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-Methyl-4-pyriMidinyl]hydrazide, (αR)-

Base Information

• Chemical Name: Cyclopentanepropanoic acid, α-[(forMylhydroxyaMino)Methyl]-, 2-[5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-Methyl-4-pyriMidinyl]hydrazide, (αR)-
• CAS No.: 1152107-25-9
• Molecular Formula: C₂₂H₃₄FN₇O₄
• Molecular Weight: 479.555
• Mol file: 1152107-25-9.mol

Synonyms:

Chemical Property of Cyclopentanepropanoic acid, α-[(forMylhydroxyaMino)Methyl]-, 2-[5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-Methyl-4-pyriMidinyl]hydrazide, (αR)-

Chemical Property:

• PKA: 8.60±0.69(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)

Purity/Quality:

96% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopentanepropanoic acid, α-[(forMylhydroxyaMino)Methyl]-, 2-[5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-Methyl-4-pyriMidinyl]hydrazide, (αR)-

There total 29 articles about Cyclopentanepropanoic acid, α-[(forMylhydroxyaMino)Methyl]-, 2-[5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-Methyl-4-pyriMidinyl]hydrazide, (αR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-4-pyrimidinyl}hydrazino)-3-oxopropyl][(phenylmethyl)oxy]formamide (1152110-20-7) → GSK1322322 (1152107-25-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 4h;

Reference yield:

(2R)-3-cyclopentyl-2-({[(phenylmethyl)oxy]amino}methyl)propanoic acid (301684-95-7) → GSK1322322 (1152107-25-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic anhydride / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C

2.1: diethyl ether / 3 h / 20 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4,6-dichloro-5-fluoro-2-methylpyrimidine (105806-13-1) → GSK1322322 (1152107-25-9)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 80 - 85 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

[(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-4-pyrimidinyl}hydrazino)-3-oxopropyl][(phenylmethyl)oxy]formamide

(2R)-3-cyclopentyl-2-(hydroxymethyl)propanoic acid

(2R)-3-cyclopentyl-2-(hydroxymethyl)-N-[(phenylmethyl)oxy]propanamide

(3R)-3-(cyclopentylmethyl)-1-[(phenylmethyl)oxy]-2-azetidinone