(9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

Base Information

Chemical Name:(9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine
CAS No.:1089280-13-6
Molecular Formula:C₁₄H₂₀N₂O
Molecular Weight:232.326
Hs Code.:

Synonyms:(9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

Suppliers and Price of (9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

Chemical Property:

Boiling Point:344.2±42.0 °C(Predicted)
Density:1.13±0.1 g/cm3(Predicted)

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

There total 5 articles about (9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1089280-11-4
(9aS)-8-(phenylmethyl)hexahydropyrazino[2,1-c][1,4]oxazine-6,7-dione

: 1089280-13-6
(9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

Guidance literature:: (9aS)-8-(phenylmethyl)hexahydropyrazino[2,1-c][1,4]oxazine-6,7-dione; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 35 ℃; for 144.75h;

With sodium hydroxide; In diethyl ether; water; ethyl acetate; at 0 ℃; for 1h;

Reference yield:

: 1152110-17-2
1-phenyl-N-{[(3S)-4-(phenylmethyl)-3-morpholinyl]methyl}methanamine

: 1089280-13-6
(9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 120 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / diethyl ether / 144.72 h / 0 - 35 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; ethanol;

Reference yield:

: 106973-36-8
(3R)-5-oxo-4-(phenylmethyl)-3-morpholinecarboxylic acid

: 1089280-13-6
(9aS)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0 - 50 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

4: hydrogen; palladium 10% on activated carbon / ethanol / 120 h / 20 °C / Inert atmosphere

5: lithium aluminium tetrahydride / diethyl ether / 144.72 h / 0 - 35 °C / Inert atmosphere

With 4-methyl-morpholine; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene;