Technology Process of 1-(Phenylsulfonyl)-5-broMo-4-azaindole
There total 1 articles about 1-(Phenylsulfonyl)-5-broMo-4-azaindole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-1H-pyrrolo[3,2-b]pyridine;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 1h;
Inert atmosphere;
benzenesulfonyl chloride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
at 90 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 1 h / 90 °C / Inert atmosphere
2.1: sodium hydroxide; water / ethanol / 1 h / 90 °C
3.1: sodium hydride / N,N-dimethyl acetamide / 0.33 h / Cooling with ice
3.2: 0.5 h / 20 °C
4.1: bromine; pyridine / dichloromethane / 0.33 h / -78 °C
5.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; triethylamine / toluene / 80 °C
With
pyridine; tetrakis(triphenylphosphine) palladium(0); water; bromine; palladium diacetate; sodium hydride; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; toluene;
