3-Amino-2-oxazolidinone

Base Information

• Chemical Name: 3-Amino-2-oxazolidinone
• CAS No.: 80-65-9
• Molecular Formula: C3H6N2O2
• Molecular Weight: 102.093
• Hs Code.: 29349990
• European Community (EC) Number: 201-299-2
• NSC Number: 196570,111187,38250
• UNII: VJ7HE86A15
• DSSTox Substance ID: DTXSID00229996
• Nikkaji Number: J38.362G
• Wikidata: Q72440217
• Mol file: 80-65-9.mol

Synonyms:3-amino-2-oxazolidinone;3-amino-2-oxazolidone

Chemical Property of 3-Amino-2-oxazolidinone

Chemical Property:

• Vapor Pressure: 1.72mmHg at 25°C
• Melting Point: 65-67 °C
• Refractive Index: 1.517
• Boiling Point: 167.2 °C at 760 mmHg
• PKA: 3.24±0.20(Predicted)
• Flash Point: 54.9 °C
• PSA: 55.56000
• Density: 1.363 g/cm³
• LogP: -0.04950
• Storage Temp.: 0-6°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 102.042927438
• Heavy Atom Count: 7
• Complexity: 92.9

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COC(=O)N1N
• Uses: A metabolite of Furazolidone and Nitrofuran. Environmental contaminants; Food contaminants; Heat processing contaminants

Technology Process of 3-Amino-2-oxazolidinone

There total 8 articles about 3-Amino-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C8H14N2O4 → 3-amino-2-oxazolidinone (80-65-9)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 3h;

Reference yield: 75.0%

2-hydroxyethylhydrazine (109-84-2) + Diethyl carbonate (105-58-8,76619-83-5) → 3-amino-2-oxazolidinone (80-65-9)

Guidance literature:

With sodium methylate; for 4h; Reflux;

Reference yield: 65.0%

2-hydroxyethylhydrazine (109-84-2) + carbonic acid dimethyl ester (616-38-6) → 3-amino-2-oxazolidinone (80-65-9)

Guidance literature:

With sodium hydroxide; In methanol; at 70 ℃; for 3h;

DOI:10.1039/c5md00015g

upstream raw materials:

3-nitro-1,3-oxazolidine-2-one

carbazic acid-(2-chloro-ethyl ester)

2-hydroxyethylhydrazine

Diethyl carbonate

Downstream raw materials:

furazolidone

3-[3-(5-nitro-[2]furyl)-allylidenamino]-oxazolidin-2-one

3-[(phenylmethylene)amino]-2-oxazolidinone

2-azepan-1-yl-3-[(2-oxo-oxazolidin-3-ylimino)-methyl]-pyrido[1,2-a]pyrimidin-4-one

Refernces

Reaction of Dimethyl 3-Oxoglutarate with 1,3-Dicarbonyl Compounds

10.1021/jo00167a054

The research focuses on the decarboxylation of aromatic carboxylic acids catalyzed by Nafion-H, a sulfonated tetrafluoroethylene-based cation exchange resin. The purpose of the study was to investigate the efficiency of decarboxylation reactions for various polymethylbenzenecarboxylic acids and to understand the role of the p-methyl group in stabilizing the intermediate products. The conclusions drawn from the study indicate that the presence of p-methyl groups enhances the decarboxylation process, with mesitylenecarboxylic acid and pentamethylbenzoic acid being decarboxylated more efficiently than 2,3,5,6-tetramethylbenzoic acid. The study also involved the reaction of dimethyl 3-oxoglutarate with 1,3-dicarbonyl compounds, leading to the formation of various cyclic compounds, including bicyclo[3.3.1]nonanes and isophthalates.

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