2-Hydrazinoethanol

Base Information

• Chemical Name: 2-Hydrazinoethanol
• CAS No.: 109-84-2
• Deprecated CAS: 856640-34-1
• Molecular Formula: C2H8N2O
• Molecular Weight: 76.0983
• Hs Code.: 29280000
• European Community (EC) Number: 203-711-6
• NSC Number: 189820
• UNII: 8T2Z8Z231F
• DSSTox Substance ID: DTXSID1020728
• Nikkaji Number: J25.002C
• Wikidata: Q27121903
• Metabolomics Workbench ID: 57328
• ChEMBL ID: CHEMBL3183346
• Mol file: 109-84-2.mol

Synonyms:2-hydrazinoethanol;2-hydroxyethylhydrazine;beta-hydroxyethylhydrazine

Chemical Property of 2-Hydrazinoethanol

Chemical Property:

• Appearance/Colour: Clear colorless oily liquid
• Vapor Pressure: 0.015mmHg at 25°C
• Melting Point: -70 °C(lit.)
• Refractive Index: n20/D 1.493(lit.)
• Boiling Point: 248.9 °C at 760 mmHg
• PKA: 14.79±0.10(Predicted)
• Flash Point: 73.9 °C
• PSA: 58.28000
• Density: 1.063 g/cm³
• LogP: -0.46680
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Water Solubility.: Soluble in water, alcohols and glycols.
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 76.063662883
• Heavy Atom Count: 5
• Complexity: 17.1

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxyethylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25-36/37/38-40-25
• Safety Statements: 23-26-36/37/39-45-60-20

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CO)NN
• Uses: Intermediate, plant growth regulator, flowering inducer for pineapples. (2-Hydroxyethyl)hydrazine is used as a plant growth regulant, a component in jet fuels, intermediate for organic synthesis especially heterocycles used in agrochemicals, pharmaceuticals, stabilizers and polymerizations, Chain extender for urethane formulations, corrosion inhibitor.

Technology Process of 2-Hydrazinoethanol

There total 8 articles about 2-Hydrazinoethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

oxirane (75-21-8,99932-75-9) → 2-hydroxyethylhydrazine (109-84-2)

Guidance literature:

With hydrazine hydrate; at 0 - 60 ℃; under 7500.75 - 18751.9 Torr; Inert atmosphere;

Reference yield: 70.0%

2-bromoethanol (540-51-2) → 2-hydroxyethylhydrazine (109-84-2)

Guidance literature:

2-bromoethanol; With sodium hydroxide; In water; at 100 ℃; for 3h;

With hydrazine hydrate; In water; at 70 ℃;

Reference yield:

ethanolamine (141-43-5) → 2-hydroxyethylhydrazine (109-84-2)

Guidance literature:

With potassium hydroxide; at 95 ℃;

DOI:10.1021/jo01157a014

upstream raw materials:

oxirane

ethanolamine

methanol

hydrazine hydrate

Downstream raw materials:

5-nitro-furfural-[2-(2-hydroxy-ethyl)-semicarbazone]

furazolidone

5-amino-4-cyano-1-(2-hydroxyethyl)-pyrazole

5-amino-4-ethoxycarbonyl-1-(2'-hydroxyethyl)-pyrazole

Refernces

• 1、 Goutelle,Pasquet,Stephan,Bougrine,Delalu. "Kinetic studies of hydrazine and 2-hydroxyethylhydrazine alkylation by 2-chloroethanol: influence of a strong base in the medium". . p. 382 - 393. Retrieved 2009.
• 2、 -. "Synthetic method of furazolidone metabolite AOZ". Paragraph 0022; 0025. . Retrieved 2020/07/13.
• 3、 -. "NOVEL BACTERIAL COLONY SENSING REGULATOR AND MEDICAL USE". Paragraph 0041; 0042. . Retrieved 2015/12/19.