3-(Phenylmethyleneamino)-2-oxazolidone

Base Information

• Chemical Name: 3-(Phenylmethyleneamino)-2-oxazolidone
• CAS No.: 4341-14-4
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.202
• Mol file: 4341-14-4.mol

Synonyms:2-Oxazolidone, 3-(benzylideneamino)-;3-(Phenylmethyleneamino)-2-oxazolidone;2-Oxazolidone, 3-(phenylmethyleneamino)-;3-{[(E)-phenylmethylidene]amino}-1,3-oxazolidin-2-one;C10H11N2O2;C10-H11-N2-O2;N-benzylidene-3-amino-2-oxazolidone;STK063356;AKOS003595992;NSC 529419;LS-100713

Chemical Property of 3-(Phenylmethyleneamino)-2-oxazolidone

Chemical Property:

• Vapor Pressure: 0.00175mmHg at 25°C
• Boiling Point: 293.2°Cat760mmHg
• Flash Point: 131.1°C
• Density: 1.22g/cm³
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 190.074227566
• Heavy Atom Count: 14
• Complexity: 234

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(=O)N1N=CC2=CC=CC=C2
• Isomeric SMILES: C1COC(=O)N1/N=C/C2=CC=CC=C2

Technology Process of 3-(Phenylmethyleneamino)-2-oxazolidone

There total 5 articles about 3-(Phenylmethyleneamino)-2-oxazolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-hydroxyethylhydrazine (109-84-2) + benzaldehyde (100-52-7) + carbonic acid dimethyl ester (616-38-6) → 3-[(phenylmethylene)amino]-2-oxazolidinone (4341-14-4)

Guidance literature:

2-hydroxyethylhydrazine; carbonic acid dimethyl ester; With sodium; In methanol; Inert atmosphere; Reflux;

benzaldehyde; With toluene-4-sulfonic acid; In toluene; for 8h; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.9b01163

Reference yield:

2-(2-hydroxy-ethyl)-semicarbazide; hydrochloride (88927-83-7) → 3-[(phenylmethylene)amino]-2-oxazolidinone (4341-14-4)

Guidance literature:

With hydrogenchloride; anschliessend Behandeln mit Benzaldehyd in Aethanol;

DOI:10.1021/ja01613a074

Reference yield:

2-hydroxyethylhydrazine (109-84-2) + benzaldehyde (100-52-7) → 3-[(phenylmethylene)amino]-2-oxazolidinone (4341-14-4)

Guidance literature:

With ethanol; anschliessend mit Chlorokohlensaeure-aethylester, Natriumacetat und wss. NaOH;

DOI:10.1021/ja01613a074

upstream raw materials:

3-amino-2-oxazolidinone

benzaldehyde

2-(2-hydroxy-ethyl)-semicarbazide; hydrochloride

2-hydroxyethylhydrazine

Downstream raw materials:

3-benzylamino-oxazolidin-2-one