2-(Chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:2-(Chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
CAS No.:89567-04-4
Molecular Formula:C11H12ClN3S
Molecular Weight:253.755
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20366276
Wikidata:Q82151407
Mol file:89567-04-4.mol

Synonyms:89567-04-4;2-(chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine;2-(Chloromethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine;2-(chloromethyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine;5-(Chloromethyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2,4,6-tetraen-3-amine;CBDivE_006645;DTXSID20366276;AKOS000583045;CS-0241845;FT-0718099;EN300-23921;J-506302;Z166648282;5-(chloromethyl)-8-thia-4,6-diazatricyclo[7.4.0.0?,?]trideca-1(9),2,4,6-tetraen-3-amine

Suppliers and Price of 2-(Chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(CHLOROMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4-AMINE 95.00%
5G
$ 1114.58

American Custom Chemicals Corporation
2-(CHLOROMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4-AMINE 95.00%
2.5G
$ 932.60

American Custom Chemicals Corporation
2-(CHLOROMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4-AMINE 95.00%
1G
$ 692.46

AK Scientific
2-(Chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
2.5g
$ 213.00

Total 8 raw suppliers

Chemical Property of 2-(Chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine

Chemical Property:

PSA：80.04000
Density:1.439g/cm³
LogP:3.47230
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:253.0440463
Heavy Atom Count:16
Complexity:266

Purity/Quality:

97% ^*data from raw suppliers

2-(CHLOROMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2=C(C1)C3=C(N=C(N=C3S2)CCl)N

Technology Process of 2-(Chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine

There total 2 articles about 2-(Chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.4%

: 4651-91-6
3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene

: 107-14-2
chloroacetonitrile

: 89567-04-4
2-chloromethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl-amine

Guidance literature:: 3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene; chloroacetonitrile; In 1,4-dioxane; at 80 ℃; for 0.166667h;

With hydrogenchloride; In 1,4-dioxane; water; for 6h;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 89567-04-4
2-chloromethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: morpholine; sulfur

2: hydrogenchloride / 1,4-dioxane / 20 °C

With morpholine; hydrogenchloride; sulfur; In 1,4-dioxane; 1: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2013.03.020

Reference yield: 59.1%

: 89567-04-4
2-chloromethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl-amine

: 75-05-8,26809-02-9
acetonitrile

: 77373-45-6
4-amino-2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine

Guidance literature:: 2-chloromethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl-amine; acetonitrile; In 1,4-dioxane; at 80 ℃; for 0.166667h;

With hydrogenchloride; In 1,4-dioxane; water; at 80 ℃;
DOI:10.1111/cbdd.12687