N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide

Base Information

• Chemical Name: N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide
• CAS No.: 1443221-52-0
• Molecular Formula: C₂₆H₂₁N₅OS₂
• Molecular Weight: 483.618

Synonyms:N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide

Chemical Property of N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide

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Technology Process of N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide

There total 7 articles about N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-benzoyl-3-[1-diethylamino-1-phenylmeth-(E)-ylidene]thiourea (952611-10-8) + 2-chloromethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl-amine (89567-04-4) → N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide (1443221-52-0)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2013.03.020

Reference yield:

benzoyl chloride (98-88-4) → N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide (1443221-52-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutylammomium bromide / benzene / 20 °C

2: toluene / 3 h / -5 - 20 °C

3: N,N-dimethyl-formamide / 48 h / 20 °C

With tetrabutylammomium bromide; In N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1016/j.ejmech.2013.03.020

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]benzamide (1443221-52-0)

Guidance literature:

Multi-step reaction with 3 steps

1: morpholine; sulfur

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: N,N-dimethyl-formamide / 48 h / 20 °C

With morpholine; hydrogenchloride; sulfur; In 1,4-dioxane; N,N-dimethyl-formamide; 1: |Gewald Aminoheterocycles Synthesis;

DOI:10.1016/j.ejmech.2013.03.020

upstream raw materials:

Benzoyl isothiocyanate

benzoyl chloride

N,N-diethylbenzamidine

benzonitrile

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