3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPANOICACID

Base Information

• Chemical Name: 3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPANOICACID
• CAS No.: 99855-02-4
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Hs Code.: 2933990090
• Mol file: 99855-02-4.mol

Synonyms:3-(2,3-Dihydro-1H-indol-1-yl)propionic acid, 3-(2,3-Dihydro-1H-indol-1-yl)propanoic acid;3-(Indolin-1-yl)propanoic acid

Chemical Property of 3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPANOICACID

Chemical Property:

• Vapor Pressure: 1.49E-06mmHg at 25°C
• Melting Point: 75～77℃
• Boiling Point: 383.1°C at 760 mmHg
• Flash Point: 185.5°C
• PSA: 40.54000
• Density: 1.208g/cm³
• LogP: 1.58880
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-[2,3-Dihydro-1-(1H)-indole]propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPANOICACID

There total 5 articles about 3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPANOICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-indoline (496-15-1) → 3-indolin-1-yl-propionic acid (99855-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; copper (I)-chloride

2: aqueous alkaline solution

With alkaline solution; acetic acid; copper(l) chloride;

DOI:10.1021/jo01096a618 DOI:10.1021/jo01096a026

Reference yield:

3-(indolin-1-yl)propanenitrile (91349-96-1) → 3-indolin-1-yl-propionic acid (99855-02-4)

Guidance literature:

With alkaline solution;

DOI:10.1021/jo01096a618 DOI:10.1021/jo01096a026

Reference yield:

phenylhydrazine (100-63-0) → 3-indolin-1-yl-propionic acid (99855-02-4)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 40 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

3: potassium carbonate / N,N-dimethyl-formamide / 100 °C

4: methanol; water; lithium hydroxide

With methanol; water; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; lithium hydroxide; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.01.117

upstream raw materials:

3-(indolin-1-yl)propanenitrile

1-indoline

methyl 3-(indolin-1-yl)propanoate

phenylhydrazine

Downstream raw materials:

5-benzyl-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-6-one

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