BenzeneMethanol, 4-broMo-.alpha.-(trichloroMethyl)-

Base Information

• Chemical Name: BenzeneMethanol, 4-broMo-.alpha.-(trichloroMethyl)-
• CAS No.: 21757-86-8
• Molecular Formula: C8H6BrCl3O
• Molecular Weight: 304.398
• Mol file: 21757-86-8.mol

Synonyms:p-bromophenyl(trichloromethyl)carbinol;1-(4-Brom-phenyl)-2,2,2-trichlor-aethanol;Trichlormethyl-(4-brom-phenyl)-carbinol;1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol;1-(4-bromo-phenyl)-2,2,2-trichloro-ethanol;

Chemical Property of BenzeneMethanol, 4-broMo-.alpha.-(trichloroMethyl)-

Chemical Property:

• Vapor Pressure: 1.03E-05mmHg at 25°C
• Boiling Point: 356.9°Cat760mmHg
• PKA: 11.72±0.20(Predicted)
• Flash Point: 169.6°C
• PSA: 20.23000
• Density: 1.781g/cm³
• LogP: 3.85270

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BenzeneMethanol, 4-broMo-.alpha.-(trichloroMethyl)-

There total 7 articles about BenzeneMethanol, 4-broMo-.alpha.-(trichloroMethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloroform (67-66-3,8013-54-5) + 4-bromo-benzaldehyde (1122-91-4) → 1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol (21757-86-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 20 ℃; for 12h;

DOI:10.1021/jo8007644

Reference yield: 90.0%

chloral hydrate (302-17-0) + 2,4,6-tris(4-bromophenyl)boroxin (7519-94-0) → 1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol (21757-86-8)

Guidance literature:

With C₆₂H₇₄Cl₂N₄Pd₂S₂; potassium carbonate; In toluene; at 100 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1039/d1ra02403e

Reference yield: 82.0%

sodium trichloroacetate (650-51-1) + 4-bromo-benzaldehyde (1122-91-4) → 1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol (21757-86-8)

Guidance literature:

With malonic acid; In dimethyl sulfoxide; at 20 ℃; for 0.666667h;

DOI:10.1021/jo402595r

upstream raw materials:

bromobenzene

chloral

(4-bromophenyl)magnesium bromide

1.4-dibromobenzene

Downstream raw materials:

2-Amino-5-(4-bromo-phenyl)-3-cyano-4-oxo-cyclopent-2-enecarboxylic acid ethyl ester

3-(4-Bromo-phenyl)-2,5-bis-ethoxycarbonyl-4-oxo-hexanedioic acid diethyl ester

1-(p-bromophenyl)-2,2-dichloroethanol

1-Brom-4-<1,2,2,2-tetrachlor-ethyl>-benzol