benzyl pyridin-2-yl carbonate

Base Information

• Chemical Name: benzyl pyridin-2-yl carbonate
• CAS No.: 96452-48-1
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.235
• Mol file: 96452-48-1.mol

Synonyms:benzyl pyridin-2-yl carbonate

Chemical Property of benzyl pyridin-2-yl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl pyridin-2-yl carbonate

There total 4 articles about benzyl pyridin-2-yl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-Pyridone (142-08-5,1199357-22-6) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl pyridin-2-yl carbonate (96452-48-1)

Guidance literature:

In quinoline; dichloromethane; for 12h; Ambient temperature;

Reference yield: 80.0%

2-hydroxypyridin (142-08-5) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl pyridin-2-yl carbonate (96452-48-1)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1246/bcsj.58.3570

Reference yield:

L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → benzyl pyridin-2-yl carbonate (96452-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (C₂H₅)3N / dimethylformamide; H₂O / 6 h / Ambient temperature

2: 80 percent / (C₂H₅)3N / CH₂Cl₂ / 1 h / Ambient temperature

With triethylamine; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.58.3570

upstream raw materials:

2-Pyridone

benzyl chloroformate

2-hydroxypyridin

L-proline

Downstream raw materials:

N-Cbz-Ala

(S)-N-(benzyloxycarbonyl)valine

N-(benzyloxycarbonyl)-L-serine

Z-Leu-OH