CARBAMIC ACID, N-(6,8-DIFLUORO-2H-1-BENZOPYRAN-3-YL)-, METHYL ESTER

Base Information

• Chemical Name: CARBAMIC ACID, N-(6,8-DIFLUORO-2H-1-BENZOPYRAN-3-YL)-, METHYL ESTER
• CAS No.: 1034001-13-2
• Molecular Formula: C₁₁H₉F₂NO₃
• Molecular Weight: 241.194
• Hs Code.: 2932990090
• Mol file: 1034001-13-2.mol

Synonyms:CARBAMIC ACID, N-(6,8-DIFLUORO-2H-1-BENZOPYRAN-3-YL)-, METHYL ESTER;MethylesterN-(6,8-difluoro-2H-1-benzopyran-3-yl)-carbamicacid

Chemical Property of CARBAMIC ACID, N-(6,8-DIFLUORO-2H-1-BENZOPYRAN-3-YL)-, METHYL ESTER

Chemical Property:

• PSA: 51.05000
• LogP: 2.25850

Purity/Quality:

99%, ^*data from raw suppliers

Methyl N-(6,8-difluoro-2H-1-benzopyran-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CARBAMIC ACID, N-(6,8-DIFLUORO-2H-1-BENZOPYRAN-3-YL)-, METHYL ESTER

There total 6 articles about CARBAMIC ACID, N-(6,8-DIFLUORO-2H-1-BENZOPYRAN-3-YL)-, METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

6,8-difluoro-2H-chromene-3-carboxamide (1151797-94-2) → methyl 6,8-difluoro-2H-chromen-3-yl-carbamate (1034001-13-2)

Guidance literature:

With sodium hypochlorite; sodium hydroxide; In methanol; at 25 ℃; for 24h;

DOI:10.1021/op300012d

Reference yield: 74.0%

methanol (67-56-1) + 6,8-difluoro-2H-chromene-3-carboxamide (1151797-94-2) → methyl 6,8-difluoro-2H-chromen-3-yl-carbamate (1034001-13-2)

Guidance literature:

methanol; 6,8-difluoro-2H-chromene-3-carboxamide; With sodium hypochlorite; at 5 - 10 ℃; for 0.5h; Industry scale;

With sodium hydroxide; In water; at 10 - 25 ℃; for 20.5 - 24.5h; Product distribution / selectivity; Industry scale;

Reference yield:

methanol (67-56-1) + C10H5F2N3O2 (1151797-95-3) → methyl 6,8-difluoro-2H-chromen-3-yl-carbamate (1034001-13-2)

Guidance literature:

In dichloromethane; at 60 ℃; Heating / reflux;

upstream raw materials:

methanol

6,8-difluoro-2H-chromene-3-carboxamide

C₁₀H₅F₂N₃O₂

6,8-difluoro-2H-chromene-3-carbonitrile

Downstream raw materials:

(R)-3-amino-6,8-difluorochroman

(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione

C₉H₇BrF₂O₂

C₁₂H₁₁BrF₂O₄

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