NSI-189

Base Information

Chemical Name:NSI-189
CAS No.:1270138-41-4
Molecular Formula:C22H33N4O5P
Molecular Weight:464.494981
Hs Code.:
Mol file:1270138-41-4.mol

Synonyms:Methanone,(2-((3-methylbutyl)amino)-3-pyridinyl)(4-(phenylmethyl)-1-piperazinyl)-,phosphate (1:1);UNII-HX0VO60T62;NSI-189 phosphate;

Suppliers and Price of NSI-189

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 42 raw suppliers

Chemical Property of NSI-189

Chemical Property:

PSA：136.04000
LogP:2.51780

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description NSI-189 phosphate (NSI-189) is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.
Uses NSI-189 is a novel oral drug which was developed by Neuralstem for the treatment of cognitive disorders. Now the drug is being tested in phase II of clinical trials in patients suffering from major depressive disorder. The mechanism of NSI-189 action is explained by its ability to stimulate the generation of new neurons in the hippocampus, however the exact target molecule is still unknown.
Biological Functions NSI-189 is a neurogenic. It allows the brain to develop healthy brain cells at a quicker rate than usual, which means that people suffering from depression, mental disorders, or degenerative conditions might all benefit from using NSI-189. NSI-189 has also been shown to possess an anti-stress effect.Possesses antidepressant properties that may improve cognitive function, treat traumatic brain injury, Alzheimer's Disease (AD), Post-Traumatic Stress Disorder (PTSD), and stroke, and prevent cognitive and memory decline in aging.NSI-189 can increase neurotrophic factors such as Stem Cell Factor (SCF), Brain-Derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and Glial-Derived Neurotrophic Factor (GDNF).NSI-189 may effectively treat MDD as well as other psychiatric disorders by increasing neurogenesis (growth) in the hippocampus.NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells.NSI 189 is currently in research for treating other neurological disorders such as Alzheimer's disease, brain injury, stroke, traumatic stress disorder.A rise in the energy levels, and increase libido, and sexual performance has been noted by some individuals.NSI-189 may be able to protect nerves from toxicity in diabetes. It may help with nerve pain and neuropathy in diabetes.

Technology Process of NSI-189

There total 5 articles about NSI-189 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1270138-40-3
(4-benzylpiperazin-1-yl)-[2-(3-methyl-butylamino)pyridin-3-yl] methanone

: 1270138-41-4
C₂₂H₃₀N₄O*(x)H₃O₄P

Guidance literature:: With phosphoric acid; In ethanol; water; at 75 ℃; for 0.5h;

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 1270138-41-4
C₂₂H₃₀N₄O*(x)H₃O₄P

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / isopropyl alcohol / 1 h / 20 - 35 °C

2: hydrogenchloride / isopropyl alcohol / 9 h / 50 °C

3: triethylamine / acetonitrile / 3.5 h / 50 °C

4: acetonitrile / 19 h / 85 °C

5: phosphoric acid / ethanol; water / 0.5 h / 75 °C

With hydrogenchloride; phosphoric acid; triethylamine; In ethanol; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 551921-02-9
1-(2-chloronicotinoyl)-4-tert-butoxycarbonylpiperazine

: 1270138-41-4
C₂₂H₃₀N₄O*(x)H₃O₄P

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / isopropyl alcohol / 9 h / 50 °C

2: triethylamine / acetonitrile / 3.5 h / 50 °C

3: acetonitrile / 19 h / 85 °C

4: phosphoric acid / ethanol; water / 0.5 h / 75 °C

With hydrogenchloride; phosphoric acid; triethylamine; In ethanol; water; isopropyl alcohol; acetonitrile;