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Encyclopedia

NSI-189

Base Information Edit
NSI-189

Synonyms:NSI-189;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone NSI189;NSI-189 [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;NSI-189, >=98%;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]

Suppliers and Price of NSI-189
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • AK Scientific
  • NIS-189
  • 5mg
  • $ 57.20
  • AK Scientific
  • (4-Benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone
  • 5g
  • $ 560.00
  • American Custom Chemicals Corporation
  • (4-BENZYLPIPERAZIN-1-YL)(2-(ISOPENTYLAMINO)PYRIDIN-3-YL)METHANONE 95.00%
  • 5MG
  • $ 500.46
  • ApexBio Technology
  • NSI-189
  • 5mg
  • $ 118.00
  • ApexBio Technology
  • NSI-189
  • 50mg
  • $ 693.00
  • ApexBio Technology
  • NSI-189
  • 10mg
  • $ 198.00
  • ApexBio Technology
  • NSI-189
  • 100mg
  • $ 1331.00
  • Biorbyt Ltd
  • NSI-189 >98%
  • 250 mg
  • $ 1356.60
  • Biorbyt Ltd
  • NSI-189 >98%
  • 100 mg
  • $ 690.20
  • Biorbyt Ltd
  • NSI-189 >98%
  • 1000 mg
  • $ 2691.10
Total 141 raw suppliers
Chemical Property of NSI-189 Edit
Chemical Property:
  • Boiling Point:534.7±50.0 °C(Predicted) 
  • PKA:6.18±0.10(Predicted) 
  • PSA:48.47000 
  • Density:1.134±0.06 g/cm3(Predicted) 
  • LogP:3.44640 
Purity/Quality:

99% *data from raw suppliers

NIS-189 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Description NSI-189 is an investigational drug being developed by Neuralstem Inc., a biopharmaceutical company. NSI-189 is a small molecule in clinical development for major depressive disorder (MDD) and in preclinical development for Angelman syndrome, irradiation-induced cognitive impairment, Type 1 and Type 2 diabetes, and stroke. NSI-189 was studied in phase I and II clinical trials for the treatment of major depressive disorder. As of July 2017, NSI-189 has failed to meet effectiveness outcomes for depression in phase II trials.
  • Uses NSI-189 is an experimental, potential antidepressant, for the treatment for major depressive disorder (MDD), as well as for cognitive impairment and neurodegeneration.
Technology Process of NSI-189

There total 9 articles about NSI-189 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With trifluoroacetic acid; In dichloromethane; for 2h; Reflux;
Guidance literature:
Multi-step reaction with 5 steps
1: thionyl chloride; N,N-dimethyl-formamide / 3.08 h / 65 °C
2: triethylamine / isopropyl alcohol / 1 h / 20 - 35 °C
3: hydrogenchloride / isopropyl alcohol / 9 h / 50 °C
4: triethylamine / acetonitrile / 3.5 h / 50 °C
5: acetonitrile / 19 h / 85 °C
With hydrogenchloride; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In isopropyl alcohol; acetonitrile;
Refernces Edit
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