(Z)-5-Chloro-3-(alpha-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide monosodium salt

Base Information

• Chemical Name: (Z)-5-Chloro-3-(alpha-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide monosodium salt
• CAS No.: 119784-94-0
• Molecular Formula: C₁₄H₈ClN₂O₃S*Na
• Molecular Weight: 342.738
• Mol file: 119784-94-0.mol

Synonyms:1H-Indole-1-carboxamide,5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, monosodium salt,(3Z)- (9CI); 1H-Indole-1-carboxamide,5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, monosodium salt,(Z)-; CP 66248-2; Tenidap sodium

Chemical Property of (Z)-5-Chloro-3-(alpha-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide monosodium salt

Chemical Property:

• Vapor Pressure: 7.42E-13mmHg at 25°C
• Melting Point: 237-238°
• Boiling Point: 553.4°Cat760mmHg
• Flash Point: 288.5°C
• PSA: 115.69000
• Density: g/cm³
• LogP: 3.70440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Anti-inflammatory (osteoarthritis and rheumatoid arthritis).

Technology Process of (Z)-5-Chloro-3-(alpha-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide monosodium salt

There total 4 articles about (Z)-5-Chloro-3-(alpha-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide monosodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tenidap → tenidap sodium (119784-94-0)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 11h; Reflux;

DOI:10.1021/op000082b

Reference yield:

5-chloro-indolin-2-one (17630-75-0) → tenidap sodium (119784-94-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide / 7 h / Reflux

1.2: 0 - 5 °C

2.1: acetic acid / water / 1 h / 20 °C

3.1: acetic anhydride; sodium acetate / water / 1 h / 0 - 5 °C

4.1: dmap; triethylamine / N,N-dimethyl-formamide / 8 - 15 °C

5.1: sodium methylate / methanol / 11 h / 20 °C / Reflux

With dmap; sodium methylate; sodium acetate; acetic anhydride; acetic acid; triethylamine; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/op000082b

Reference yield:

C8H8ClNO2 (500572-08-7) → tenidap sodium (119784-94-0)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / water / 1 h / 20 °C

2: acetic anhydride; sodium acetate / water / 1 h / 0 - 5 °C

3: dmap; triethylamine / N,N-dimethyl-formamide / 8 - 15 °C

4: sodium methylate / methanol / 11 h / 20 °C / Reflux

With dmap; sodium methylate; sodium acetate; acetic anhydride; acetic acid; triethylamine; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/op000082b

upstream raw materials:

5-chloro-indolin-2-one

C₈H₈ClNO₂

Refernces