Pyrido[2,3-d]pyrimidine-5-carbonitrile, 1,2,3,4-tetrahydro-7-(4-methoxyphenyl)-4-oxo-2-thioxo-

Base Information

• Chemical Name: Pyrido[2,3-d]pyrimidine-5-carbonitrile, 1,2,3,4-tetrahydro-7-(4-methoxyphenyl)-4-oxo-2-thioxo-
• CAS No.: 950829-80-8
• Molecular Formula: C₁₅H₁₀N₄O₂S
• Molecular Weight: 310.336
• Mol file: 950829-80-8.mol

Synonyms:Pyrido[2,3-d]pyrimidine-5-carbonitrile, 1,2,3,4-tetrahydro-7-(4-methoxyphenyl)-4-oxo-2-thioxo-

Chemical Property of Pyrido[2,3-d]pyrimidine-5-carbonitrile, 1,2,3,4-tetrahydro-7-(4-methoxyphenyl)-4-oxo-2-thioxo-

Chemical Property:

• PSA: 130.72000
• LogP: 2.56638

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[2,3-d]pyrimidine-5-carbonitrile, 1,2,3,4-tetrahydro-7-(4-methoxyphenyl)-4-oxo-2-thioxo-

There total 2 articles about Pyrido[2,3-d]pyrimidine-5-carbonitrile, 1,2,3,4-tetrahydro-7-(4-methoxyphenyl)-4-oxo-2-thioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

6-[(4-methoxybenzylidene)amino]-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one + (E)-β-piperidino acrylonitrile (65157-84-8) → 7-(4-methoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carbonitrile (950829-80-8)

Guidance literature:

In 1,4-dioxane; for 16h; Heating;

DOI:10.3797/scipharm.2007.75.9 DOI:10.1016/j.bmc.2007.06.023

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 7-(4-methoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carbonitrile (950829-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / acetic acid / dimethylformamide / 4 h / Heating

2: 76 percent / dioxane / 16 h / Heating

With acetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.3797/scipharm.2007.75.9

upstream raw materials:

(E)-β-piperidino acrylonitrile

4-methoxy-benzaldehyde