1’-Oxobufuralol Hydrochloride

Base Information

Chemical Name:1’-Oxobufuralol Hydrochloride
CAS No.:137740-37-5
Molecular Formula:C₁₆H₂₁NO₃*ClH
Molecular Weight:311.809
Hs Code.:
Mol file:137740-37-5.mol

Synonyms:1’-Oxobufuralol Hydrochloride;1'-Oxpbufuralol Hydrochloride

Suppliers and Price of 1’-Oxobufuralol Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1’-OxobufuralolHydrochloride
1mg
$ 225.00

American Custom Chemicals Corporation
1'-OXOBUFURALOL HYDROCHLORIDE 95.00%
5MG
$ 504.22

Total 11 raw suppliers

Chemical Property of 1’-Oxobufuralol Hydrochloride

Chemical Property:

Melting Point:216-218?C
PSA：62.47000
LogP:4.24980
Storage Temp.:-20°C Freezer
Solubility.:Methanol (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1’-OxobufuralolHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.

Technology Process of 1’-Oxobufuralol Hydrochloride

There total 16 articles about 1’-Oxobufuralol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18980-21-7
4-bromo-2-ethylphenol

: 137740-37-5
1''-Oxobufuralol hydrochloride

Guidance literature:: Multi-step reaction with 16 steps

1: 1) potassium tert-butoxide / 1) tert-butyl alcohol, reflux, o.5 h, 2) tert-butyl alcohol, reflux, 8 h

2: 82 percent / N,N-dimethylaniline / 2.5 h / 193 °C

3: 84 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0 deg C to 22 deg C, 22 h

4: 75 percent / potassium hydroxide, water / dimethylsulfoxide / 3 h / 23 °C

5: 82 percent / triethylamine, 4-dimethyl-aminopyridine / CH₂Cl₂ / 10 h / Ambient temperature

6: 95 percent / benzoyl peroxiden, N-bromosuccinimide / CCl₄ / Heating; Irradiation

7: 61 percent / mercuric acetate / 2 h / Heating

8: 86 percent / ammonia, methanol / 10 h / Ambient temperature

9: 78 percent / 2 M oxalyl chloride, dimethyl sulfoxide, triethylamine / CH₂Cl₂ / -60 °C

10: 97 percent / p-toluenesulfonic acid / benzene / 4 h / Heating

11: 91 percent / sodium hydroxide, water / tetrahydrofuran / 4 h / 24 °C

12: 70 percent / pyridine, chromium trioxide / CH₂Cl₂ / 0.5 h / 23 °C

13: 1) sodium methylsulfinylmethide / 1) dimethyl sulfoxide, tetrahydrofuran, 0 deg C, 2 min, 2) tetrahydrofuran, 0 deg C, 30 min, then 25 deg C, 1 h

14: 51 percent / benzene; methanol / 16 h / Heating

15: 84 percent / hydrogen, triethylamine / 5 percent palladium on carbon / ethanol / 775.7 Torr

16: hydrochloric acid / methanol

With pyridine; chromium(VI) oxide; hydrogenchloride; methanol; dmap; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; oxalyl dichloride; dimsylsodium; potassium tert-butylate; mercury(II) diacetate; ammonia; water; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; N,N-dimethyl-aniline; triethylamine; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1002/jhet.5570280535

Reference yield:

: 135455-50-4
2-<5-bromo-2-(hydroxymethyl)benzofuran-7-yl>-2-methyl-1,3-dioxolane

: 137740-37-5
1''-Oxobufuralol hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / pyridine, chromium trioxide / CH₂Cl₂ / 0.5 h / 23 °C

2: 1) sodium methylsulfinylmethide / 1) dimethyl sulfoxide, tetrahydrofuran, 0 deg C, 2 min, 2) tetrahydrofuran, 0 deg C, 30 min, then 25 deg C, 1 h

3: 51 percent / benzene; methanol / 16 h / Heating

4: 84 percent / hydrogen, triethylamine / 5 percent palladium on carbon / ethanol / 775.7 Torr

5: hydrochloric acid / methanol

With pyridine; chromium(VI) oxide; hydrogenchloride; dimsylsodium; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; benzene;
DOI:10.1002/jhet.5570280535

Reference yield:

: 137206-66-7
2-allyl-4-bromo-6-ethylphenol

: 137740-37-5
1''-Oxobufuralol hydrochloride

Guidance literature:: Multi-step reaction with 14 steps

1: 84 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0 deg C to 22 deg C, 22 h

2: 75 percent / potassium hydroxide, water / dimethylsulfoxide / 3 h / 23 °C

3: 82 percent / triethylamine, 4-dimethyl-aminopyridine / CH₂Cl₂ / 10 h / Ambient temperature

4: 95 percent / benzoyl peroxiden, N-bromosuccinimide / CCl₄ / Heating; Irradiation

5: 61 percent / mercuric acetate / 2 h / Heating

6: 86 percent / ammonia, methanol / 10 h / Ambient temperature

7: 78 percent / 2 M oxalyl chloride, dimethyl sulfoxide, triethylamine / CH₂Cl₂ / -60 °C

8: 97 percent / p-toluenesulfonic acid / benzene / 4 h / Heating

9: 91 percent / sodium hydroxide, water / tetrahydrofuran / 4 h / 24 °C

10: 70 percent / pyridine, chromium trioxide / CH₂Cl₂ / 0.5 h / 23 °C

11: 1) sodium methylsulfinylmethide / 1) dimethyl sulfoxide, tetrahydrofuran, 0 deg C, 2 min, 2) tetrahydrofuran, 0 deg C, 30 min, then 25 deg C, 1 h

12: 51 percent / benzene; methanol / 16 h / Heating

13: 84 percent / hydrogen, triethylamine / 5 percent palladium on carbon / ethanol / 775.7 Torr

14: hydrochloric acid / methanol

With pyridine; chromium(VI) oxide; hydrogenchloride; methanol; dmap; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; oxalyl dichloride; dimsylsodium; mercury(II) diacetate; ammonia; water; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1002/jhet.5570280535