1'-oxobufuralol

Base Information

Chemical Name:1'-oxobufuralol
CAS No.:59664-01-6
Molecular Formula:C₁₆H₂₁NO₃
Molecular Weight:275.348
Hs Code.:
Mol file:59664-01-6.mol

Synonyms:1'-Oxobufuralol;Ro 03-7928

Suppliers and Price of 1'-oxobufuralol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1'-OXOBUFURALOL 95.00%
25MG
$ 1758.49

American Custom Chemicals Corporation
1'-OXOBUFURALOL 95.00%
2.5MG
$ 895.13

Total 1 raw suppliers

Chemical Property of 1'-oxobufuralol

Chemical Property:

Vapor Pressure:4.61E-08mmHg at 25°C
Boiling Point:427.3°C at 760 mmHg
Flash Point:212.2°C
PSA：62.47000
Density:1.129g/cm³
LogP:3.44780

Purity/Quality:: 1'-OXOBUFURALOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A metabolite of Bufuralol, a ?Adrenergic blocker with peripheral vasodilating activity

Technology Process of 1'-oxobufuralol

There total 15 articles about 1'-oxobufuralol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 137206-84-9
2-<(2-tert-butylamino-1-hydroxyethyl)-5-bromobenzofuran-7-yl>-2-methyl-1,3-dioxolane

: 59664-01-6
1''-oxobufuralol

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; under 775.7 Torr;
DOI:10.1002/jhet.5570280535

Reference yield:

: 18980-21-7
4-bromo-2-ethylphenol

: 59664-01-6
1''-oxobufuralol

Guidance literature:: Multi-step reaction with 15 steps

1: 1) potassium tert-butoxide / 1) tert-butyl alcohol, reflux, o.5 h, 2) tert-butyl alcohol, reflux, 8 h

2: 82 percent / N,N-dimethylaniline / 2.5 h / 193 °C

3: 84 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0 deg C to 22 deg C, 22 h

4: 75 percent / potassium hydroxide, water / dimethylsulfoxide / 3 h / 23 °C

5: 82 percent / triethylamine, 4-dimethyl-aminopyridine / CH₂Cl₂ / 10 h / Ambient temperature

6: 95 percent / benzoyl peroxiden, N-bromosuccinimide / CCl₄ / Heating; Irradiation

7: 61 percent / mercuric acetate / 2 h / Heating

8: 86 percent / ammonia, methanol / 10 h / Ambient temperature

9: 78 percent / 2 M oxalyl chloride, dimethyl sulfoxide, triethylamine / CH₂Cl₂ / -60 °C

10: 97 percent / p-toluenesulfonic acid / benzene / 4 h / Heating

11: 91 percent / sodium hydroxide, water / tetrahydrofuran / 4 h / 24 °C

12: 70 percent / pyridine, chromium trioxide / CH₂Cl₂ / 0.5 h / 23 °C

13: 1) sodium methylsulfinylmethide / 1) dimethyl sulfoxide, tetrahydrofuran, 0 deg C, 2 min, 2) tetrahydrofuran, 0 deg C, 30 min, then 25 deg C, 1 h

14: 51 percent / benzene; methanol / 16 h / Heating

15: 84 percent / hydrogen, triethylamine / 5 percent palladium on carbon / ethanol / 775.7 Torr

With pyridine; chromium(VI) oxide; methanol; dmap; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; oxalyl dichloride; dimsylsodium; potassium tert-butylate; mercury(II) diacetate; ammonia; water; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; N,N-dimethyl-aniline; triethylamine; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1002/jhet.5570280535

Reference yield:

: 135455-50-4
2-<5-bromo-2-(hydroxymethyl)benzofuran-7-yl>-2-methyl-1,3-dioxolane

: 59664-01-6
1''-oxobufuralol

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / pyridine, chromium trioxide / CH₂Cl₂ / 0.5 h / 23 °C

2: 1) sodium methylsulfinylmethide / 1) dimethyl sulfoxide, tetrahydrofuran, 0 deg C, 2 min, 2) tetrahydrofuran, 0 deg C, 30 min, then 25 deg C, 1 h

3: 51 percent / benzene; methanol / 16 h / Heating

4: 84 percent / hydrogen, triethylamine / 5 percent palladium on carbon / ethanol / 775.7 Torr

With pyridine; chromium(VI) oxide; dimsylsodium; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; benzene;
DOI:10.1002/jhet.5570280535