2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone

Base Information

• Chemical Name: 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone
• CAS No.: 152122-41-3
• Molecular Formula: C19H24FNO2Si
• Molecular Weight: 345.489
• Hs Code.: 2933399090
• Mol file: 152122-41-3.mol

Synonyms:2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone

Chemical Property of 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone

Chemical Property:

• PSA: 39.19000
• LogP: 5.16650

Purity/Quality:

2-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-1-(4-FLUOROPHENYL)-2-(4-PYRIDINYL)-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone

There total 7 articles about 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone (152122-41-3)

Guidance literature:

Reference yield: 79.0%

4-fluorobenzoic acid ethyl ester (451-46-7) + 4-((tert-butyldimethylsilyloxy)methyl)pyridine (117423-41-3) → 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone (152122-41-3)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(98)01991-1

Reference yield: 75.0%

4-fluoro-N-methoxy-N-methylbenzamide (116332-54-8) + 4-((tert-butyldimethylsilyloxy)methyl)pyridine (117423-41-3) → 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone (152122-41-3)

Guidance literature:

With lithium diisopropyl amide;

upstream raw materials:

4-fluoro-N-methoxy-N-methylbenzamide

4-((tert-butyldimethylsilyloxy)methyl)pyridine

4-fluorobenzoic acid ethyl ester

pyridine-4-methanol

Downstream raw materials:

4-(4-Fluorophenyl)-2-(2-methylthiophenyl)-5-(pyridin-4-yl)-1H-imidazole

4-(4-Fluorophenyl)-2-(4-methylthiophenyl)-5-(pyridin-4-yl)-1H-imidazole

6-amino-3-(pyridin-4-yl)-2-(4-fluorophenyl)-7-aza-indole

2-(4-Fluoro-phenyl)-4-methoxy-3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-6-ylamine

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