4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE

Base Information

• Chemical Name: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE
• CAS No.: 116332-54-8
• Molecular Formula: C9H10FNO2
• Molecular Weight: 183.182
• Hs Code.: 2924299090
• Mol file: 116332-54-8.mol

Synonyms:4-Fluoro-N-methoxy-N-methylbenzamide;BENZAMIDE, 4-FLUORO-N-METHOXY-N-METHYL-;

Chemical Property of 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.51
• Boiling Point: 301.6±25.0 °C(Predicted)
• PSA: 29.54000
• Density: 1.179±0.06 g/cm3(Predicted)
• LogP: 1.45910
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Fluoro-n-methoxy-n-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE

There total 12 articles about 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 4-fluorobenzoyl chloride (403-43-0) → 4-fluoro-N-methoxy-N-methylbenzamide (116332-54-8)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h;

DOI:10.1016/S0968-0896(96)00212-X

Reference yield: 100.0%

4-fluorobenzoyl chloride (403-43-0) + N-methoxymethyl amine hydrochloride → 4-fluoro-N-methoxy-N-methylbenzamide (116332-54-8)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield: 96.0%

4-Fluorobenzoic acid (456-22-4) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 4-fluoro-N-methoxy-N-methylbenzamide (116332-54-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2012.05.059

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

4-fluorobenzoyl chloride

N,0-dimethylhydroxylamine

4-Fluorobenzoic acid

Downstream raw materials:

2-(4-fluoro-phenyl)-1-pyridin-2-yl-ethanone

2-(4-Cyanophenyl)-4-(4-fluorophenyl)-1-N-hydroxy-5-(4-pyridyl)imidazole

lithium diisopropyl amide

2-bromo-5-(4-fluorophenylcarbonyl)thiophene

Refernces

• 1、 Seerden, Jean-Paul G.,Leusink-Ionescu, Gabriela,Leguijt, Robin,Saccavini, Catherine,Gelens, Edith,Dros, Bas,Woudenberg-Vrenken, Titia,Molema, Grietje,Kamps, Jan A.A.M.,Kellogg, Richard M.. "Syntheses and structure-activity relationships for some triazolyl p38α MAPK inhibitors". . p. 1352 - 1357. Retrieved 2014.
• 2、 Yin, Qi,Wen, Xiaolu,Chen, Yiwei,Gong, Xiangnan,Hu, Lin. "Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes". supporting information. p. 7529 - 7534. Retrieved 2021/10/02.
• 3、 Yang, Yang,Liu, Jian,Kamounah, Fadhil S.,Ciancaleoni, Gianluca,Lee, Ji-Woong. "A CO2-Catalyzed Transamidation Reaction". . p. 16867 - 16881. Retrieved 2021/11/18.