(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate

Base Information

Chemical Name:(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate
CAS No.:102491-70-3
Molecular Formula:C21H20F3NO6
Molecular Weight:439.388
Hs Code.:
Mol file:102491-70-3.mol

Synonyms:(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate;2,2,2-Trifluoro-N-[5,6,7,9-tetrahydro-10-hydroxy-1,2,3-triMethoxy-9-oxobenzo[a]heptalen-7-yl]-acetaMide

Suppliers and Price of (R/S)-N-Deacetyl Colchiceine N-Trifluroracetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R/S)-N-DeacetylColchiceineN-Trifluroracetate
50mg
$ 260.00

Biosynth Carbosynth
(R/S)-N-Deacetyl colchiceine N-trifluoroacetate
250 mg
$ 1530.00

Biosynth Carbosynth
(R/S)-N-Deacetyl colchiceine N-trifluoroacetate
100 mg
$ 840.00

Biosynth Carbosynth
(R/S)-N-Deacetyl colchiceine N-trifluoroacetate
50 mg
$ 462.00

Biosynth Carbosynth
(R/S)-N-Deacetyl colchiceine N-trifluoroacetate
25 mg
$ 254.50

Biosynth Carbosynth
(R/S)-N-Deacetyl colchiceine N-trifluoroacetate
10 mg
$ 139.80

Total 2 raw suppliers

Chemical Property of (R/S)-N-Deacetyl Colchiceine N-Trifluroracetate

Chemical Property:

PSA：97.58000
LogP:3.95130
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Very Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

(R/S)-N-DeacetylColchiceineN-Trifluroracetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Colchiceine derivative.

Technology Process of (R/S)-N-Deacetyl Colchiceine N-Trifluroracetate

There total 3 articles about (R/S)-N-Deacetyl Colchiceine N-Trifluroracetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 73307-44-5,68296-64-0
7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

: 407-25-0
trifluoroacetic anhydride

: 102491-70-3
(+/-)-N-(trifluoroacetyl)deacetylcolchiceine

Guidance literature:: With sodium carbonate; In diethyl ether; for 2.5h; Ambient temperature;
DOI:10.1021/jo00363a021

Reference yield:

: 209810-38-8,54192-66-4
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide

: 102491-70-3
(+/-)-N-(trifluoroacetyl)deacetylcolchiceine

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / 20percent H₂SO₄ / acetic acid / 5 h / 80 - 90 °C

2: 79 percent / Na₂CO₃ / diethyl ether / 2.5 h / Ambient temperature

With sulfuric acid; sodium carbonate; In diethyl ether; acetic acid;
DOI:10.1021/jo00363a021