(S)-ALPHA-PHENYL-1-PIPERIDINEETHANAMINE

Base Information

• Chemical Name: (S)-ALPHA-PHENYL-1-PIPERIDINEETHANAMINE
• CAS No.: 148054-65-3
• Molecular Formula: C13H20N2
• Molecular Weight: 204.315
• Mol file: 148054-65-3.mol

Synonyms:(S)-ALPHA-PHENYL-1-PIPERIDINEETHANAMINE

Chemical Property of (S)-ALPHA-PHENYL-1-PIPERIDINEETHANAMINE

Chemical Property:

• Boiling Point: 313.0±22.0 °C(Predicted)
• PKA: 10.47±0.10(Predicted)
• PSA: 29.26000
• Density: 1.020±0.06 g/cm3(Predicted)
• LogP: 2.81050

Purity/Quality:

(S)-ALPHA-PHENYL-1-PIPERIDINEETHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-ALPHA-PHENYL-1-PIPERIDINEETHANAMINE

There total 13 articles about (S)-ALPHA-PHENYL-1-PIPERIDINEETHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(S)-2-Amino-2-phenyl-1-piperidin-1-yl-ethanone (889864-59-9) → (S)-(+)-1-(2-amino-2-phenylethyl)piperidine (148054-65-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4020(01)86278-5

Reference yield: 41.0%

(E/Z)-1-(2-hydroximino-2-phenylethyl)piperidine (7101-04-4) → (S)-(+)-1-(2-amino-2-phenylethyl)piperidine (148054-65-3) + (R)-(-)-1-(2-amino-2-phenylethyl)piperidine (142950-82-1)

Guidance literature:

(E/Z)-1-(2-hydroximino-2-phenylethyl)piperidine; With sodium hydroxide; aluminum nickel; In ethanol;

With dikegulac; In ethanol;

DOI:10.1515/znb-2002-0409

Reference yield:

(S)-1-phenyl-2-(piperidin-1-yl)ethan-1-ol (83829-03-2) + (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol (154472-05-6,4641-59-2) → (S)-(+)-1-(2-amino-2-phenylethyl)piperidine (148054-65-3)

Guidance literature:

(S)-1-phenyl-2-(piperidin-1-yl)ethan-1-ol; (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol; With methanesulfonyl chloride; triethylamine; In diethyl ether; at 0 - 20 ℃; for 0.5h;

With ammonia; water; In diethyl ether; at 20 ℃; for 16h;

upstream raw materials:

(S)-2-Amino-2-phenyl-1-piperidin-1-yl-ethanone

(E/Z)-1-(2-hydroximino-2-phenylethyl)piperidine

piperidine

tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

Downstream raw materials:

Methyl-[((S)-2-oxo-1-phenyl-2-piperidin-1-yl-ethylcarbamoyl)-methyl]-carbamic acid benzyl ester

N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine

(S)-N-benzhydryl-1-phenyl-2-(piperidin-1-yl)ethanamine