N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine
• CAS No.: 1039631-76-9
• Molecular Formula: C₂₂H₃₅N₃O₂
• Molecular Weight: 373.539
• Mol file: 1039631-76-9.mol

Synonyms:N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine

Chemical Property of N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine

There total 1 articles about N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (109431-87-0,83220-73-9) + (S)-(+)-1-(2-amino-2-phenylethyl)piperidine (148054-65-3) → N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine (1039631-76-9)

Guidance literature:

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate; With trifluoromethanesulfonic acid anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -30 ℃; for 0.916667h;

(S)-(+)-1-(2-amino-2-phenylethyl)piperidine; In dichloromethane; at 20 ℃; for 24h; Further stages.;

DOI:10.1021/jo8005396

Reference yield: 92.0%

N-(tert-butoxycarbonyl)-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine (1039631-76-9) → N-methyl-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine (1039631-94-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 60 ℃; for 6h;

DOI:10.1021/jo8005396

upstream raw materials:

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

(S)-(+)-1-(2-amino-2-phenylethyl)piperidine

Downstream raw materials:

N-methyl-3-(S)-(1-(S)-phenyl-2-N'-piperidinylethyl)aminopyrrolidine