3’-O-Benzyl-(1R)-hydroxy Tapentadol

Base Information

Chemical Name:3’-O-Benzyl-(1R)-hydroxy Tapentadol
CAS No.:1004315-82-5
Molecular Formula:C₂₁H₂₉NO₂
Molecular Weight:327.467
Hs Code.:
Mol file:1004315-82-5.mol

Synonyms:3’-O-Benzyl-(1R)-hydroxy Tapentadol;(2S,3R)-1-(DiMethylaMino)-3-[3-(benzyloxy)phenyl)-2-Methyl-3-pentanol;(αR)-α-[(1S)-2-(DiMethylaMino)-1-Methylethyl]-α-ethyl-3-(phenylMethoxy)benzeneMethanol;(alphaR)-alpha-[(1S)-2-(Dimethylamino)-1-methylethyl]-alpha-ethyl-3-(phenylmethoxy)benzenemethanol

Suppliers and Price of 3’-O-Benzyl-(1R)-hydroxy Tapentadol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3’-O-Benzyl-(1R)-hydroxyTapentadol
5mg
$ 165.00

Total 2 raw suppliers

Chemical Property of 3’-O-Benzyl-(1R)-hydroxy Tapentadol

Chemical Property:

PSA：32.70000
LogP:4.06090
Solubility.:Acetone, Dichloromethane, Methanol

Purity/Quality:

97% ^*data from raw suppliers

3’-O-Benzyl-(1R)-hydroxyTapentadol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Intermediate in the preparation of Tapentadol

Technology Process of 3’-O-Benzyl-(1R)-hydroxy Tapentadol

There total 5 articles about 3’-O-Benzyl-(1R)-hydroxy Tapentadol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 175774-16-0
(+)-(2R,3R)-3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol hydrochloride

: 98-88-4
benzoyl chloride

: 1004315-82-5
(+)-(1R,2R)-3-(3-benzyloxyphenyl)-1-dimethylamino-2-methylpentan-3-ol

Guidance literature:: (+)-(2R,3R)-3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol hydrochloride; With sodium hydroxide; In dichloromethane; water;

benzoyl chloride; With sodium hydride; In N,N-dimethyl-formamide; at 70 ℃; for 3h;

Reference yield: 89.0%

: 1004315-80-3
(2S)-3-(dimethylamino)-1-(3-benzyloxyphenyl)-2-methyl-1-propanone

: 2386-64-3
ethylmagnesium chloride

: 1004315-82-5
(2S,3R)-1-(dimethylamino)-3-(3-benzyloxyphenyl)-2-methyl-3-pentanol

Guidance literature:: In 2-methyltetrahydrofuran; at 0 ℃; for 5h; Inert atmosphere;

Reference yield:

: 37951-47-6
3-benzyloxyphenyl ethyl ketone

: 1004315-82-5
(2S,3R)-1-(dimethylamino)-3-(3-benzyloxyphenyl)-2-methyl-3-pentanol

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 16 h / 70 °C

2: sodium hydroxide / ethanol / 48 h / 40 °C

3: ammonium hydroxide / water; 2-methyltetrahydrofuran / pH 9.8

4: 2-methyltetrahydrofuran / 5 h / 0 °C / Inert atmosphere

With ammonium hydroxide; acetic acid; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol; water;