(Z)-ETHYL 3-(CYCLOPROPYLAMINO)-2-(2,4,5-TRIFLUORO-3-METHOXYBENZOYL)ACRYLATE

Base Information

Chemical Name:(Z)-ETHYL 3-(CYCLOPROPYLAMINO)-2-(2,4,5-TRIFLUORO-3-METHOXYBENZOYL)ACRYLATE
CAS No.:112811-70-8
Molecular Formula:C16H16F3NO4
Molecular Weight:343.303
Hs Code.:
Mol file:112811-70-8.mol

Synonyms:(Z)-ETHYL 3-(CYCLOPROPYLAMINO)-2-(2,4,5-TRIFLUORO-3-METHOXYBENZOYL)ACRYLATE;2-(2,4,5-Trifluoro-3-Methoxybenzoyl)-3-cyclopropylaMinoacrylic Acid Ethyl Ester;Ethyl 2-(2,4,5-trifluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylate

Suppliers and Price of (Z)-ETHYL 3-(CYCLOPROPYLAMINO)-2-(2,4,5-TRIFLUORO-3-METHOXYBENZOYL)ACRYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(2,4,5-Trifluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylicAcidEthylEster
500mg
$ 1320.00

Medical Isotopes, Inc.
2-(2,4,5-Trifluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylicAcidEthylEster
500 mg
$ 2200.00

Total 11 raw suppliers

Chemical Property of (Z)-ETHYL 3-(CYCLOPROPYLAMINO)-2-(2,4,5-TRIFLUORO-3-METHOXYBENZOYL)ACRYLATE

Chemical Property:

Boiling Point:463.2±45.0 °C(Predicted)
PKA:2.70±0.70(Predicted)
PSA：64.63000
Density:1.33±0.1 g/cm3(Predicted)
LogP:2.88510

Purity/Quality:

97% ^*data from raw suppliers

2-(2,4,5-Trifluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(2,4,5-Trifluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylic Acid Ethyl Ester is used in the preparation Gatifloxacin (G250000) and key intermediates for the synthesis third-generation fluoroquinolone antibiotics.

Technology Process of (Z)-ETHYL 3-(CYCLOPROPYLAMINO)-2-(2,4,5-TRIFLUORO-3-METHOXYBENZOYL)ACRYLATE

There total 14 articles about (Z)-ETHYL 3-(CYCLOPROPYLAMINO)-2-(2,4,5-TRIFLUORO-3-METHOXYBENZOYL)ACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 765-30-0
Cyclopropylamine

: 122375-85-3
ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

: 112811-70-8
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

Guidance literature:: at 0 ℃;
DOI:10.1016/j.bmc.2007.11.050

Reference yield:

: C₁₅H₁₈F₃NO₄

: 765-30-0
Cyclopropylamine

: 112811-70-8
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

Guidance literature:: In toluene; at 30 - 45 ℃; for 2h; Temperature;

Reference yield:

: 112811-66-2
2,4,5-trifluoro-3-methoxybenzoyl chloride

: 112811-70-8
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.88 g / Et₃N / toluene / 5 h / 90 °C

2: ethanol; diethyl ether / 3 h / 20 °C

With triethylamine; In diethyl ether; ethanol; toluene;
DOI:10.1016/j.ejmech.2006.07.003