(R)-tert-butyl 2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate
• CAS No.: 1207754-99-1
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.29
• Mol file: 1207754-99-1.mol

Synonyms:(R)-tert-butyl 2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate

Chemical Property of (R)-tert-butyl 2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate

Chemical Property:

• Boiling Point: 293.8±13.0 °C(Predicted)
• PKA: 14.77±0.10(Predicted)
• PSA: 49.77000
• Density: 1.055±0.06 g/cm3(Predicted)
• LogP: 1.70620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(2R)-1-Boc-2-methylpyrrolidine-2-methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate

There total 5 articles about (R)-tert-butyl 2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(R)-N-(tert-butoxycarbonyl)-α-methylproline ethyl ester (619307-07-2) → tert-butyl (R)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate (1207754-99-1)

Guidance literature:

With lithium borohydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.05.031

Reference yield: 81.0%

→ tert-butyl (R)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate (1207754-99-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

(R)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid (166170-15-6) → tert-butyl (R)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate (1207754-99-1)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 70 ℃; for 12h;

upstream raw materials:

(R)-N-(tert-butoxycarbonyl)-α-methylproline ethyl ester

(R)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid

(R)-2-Methyl-1-azacyclopentan-2-carbonsaeure

di-tert-butyl dicarbonate

Downstream raw materials:

1,1-dimethylethyl (2R)-2-methyl-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)pyrrolidine-1-carboxylate

C₂₁H₂₈F₃NO₅

C₅₆H₇₉N₅O₇